锌剂在威尔逊氏病中的应用  

Application of zinc agents in Wilson's disease

作　　者：梁晨 侯维[1] 段钟平[2,3] 郑素军 Liang Chen;Hou Wei;Duan Zhongping;Zheng Sujun(The First Department of Liver Center,Beijing YouAn Hospital,Capital Medical University,Beijing 100069,China;The Fourth Department of Liver Center,Beijing YouAn Hospital,Capital Medical University,Beijing 100069,China;Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research,Beijing YouAn Hospital,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学附属北京佑安医院肝病中心一科,北京100069 [2]首都医科大学附属北京佑安医院肝病中心四科,北京100069 [3]肝衰竭与人工肝治疗研究北京市重点实验室,北京100069

出　　处：《中华肝脏病杂志》2024年第9期850-853,共4页Chinese Journal of Hepatology

基　　金：首都卫生发展科研专项重大专项项目(2022-1-2182);北京市医院管理中心重点医学专业发展计划(扬帆计划)(ZYLX202125);北京市卫生健康委员会高层次公共卫生技术人才学科带头人(学科带头人-02-14);北京市科技新星计划交叉合作课题(20230484455);北京市自然科学基金(7202068,7222093)。

摘　　要：威尔逊氏病(WD)是一种遗传代谢性肝病,大多数患者需要终身服药来维持体内铜稳态。锌剂是治疗WD常用的药物之一。然而,目前关于锌剂治疗WD的高质量、大样本、前瞻性的临床试验较少,何时选择、如何应用锌剂治疗WD,主要是根据患者的临床表型、对锌剂的耐受性以及医生的经验来确定。该文就锌剂在WD中的应用进行综述。Wilson's disease(WD)is a kind of inherited metabolic liver disease in which most patients need lifelong medication to maintain copper homeostasis in the body.Zinc is one of the most commonly used drugs for WD treatment.However,there are currently few high-quality,large-sample,and prospective clinical trials on zinc agent-treated WD.The selection and application of zinc agents are mainly based on patients'clinical phenotype,tolerance to zinc agents,and physicians'experience in treating WD.This article summarizes the application of zinc agents in WD.

关 键 词：威尔逊氏病 肝豆状核变性 螯合剂 治疗 锌剂 

分 类 号：R575.24[医药卫生—消化系统]