微针递送系统在口腔疾病治疗中的应用研究进展  

Research advances in microneedle delivery systems for the treatment of oral diseases

作　　者：孔晓雯 王爽[2] 曹洁 KONG Xiaowen;WANG Shuang;CAO Jie(School of Stomatology,Qingdao University,Qingdao 266021,China)

机构地区：[1]青岛大学口腔医学院,山东青岛266021 [2]青岛大学基础医学院,山东青岛266021 [3]青岛大学药学院,山东青岛266021

出　　处：《青岛大学学报（医学版）》2024年第4期619-622,共4页Journal of Qingdao University(Medical Sciences)

基　　金：国家自然科学基金面上项目(32171362)。

摘　　要：微针(MN)是一种经皮给药装置,可以突破口腔黏膜屏障递送药物,具有安全、无痛、微创和高效的特点。本文就MN的种类及其在口腔疾病(例如口腔黏膜潜在恶性疾病、复发性阿弗他溃疡和口腔癌)中应用的最新进展进行综述,并探讨其应用的局限性及未来的发展方向,以期为MN在口腔疾病中的临床应用提供新的思路和方向。Microneedle(MN)is a type of device for transdermal drug delivery that can penetrate the oral mucosal barrier to deliver drugs,with the features of good safety,painlessness,minimal invasiveness,and efficient administration.The article reviews the types of MN and the latest advances in their application in oral diseases,such as potential malignant diseases of oral mucosa,recurrent aphthous ulcers,and oral cancer,as well as their limitations and the directions for future development,in order to provide new ideas and directions for the clinical application of MN in oral diseases.

关 键 词：口腔疾病 微针 生物相容性材料 投药 皮肤 药物载体 综述 

分 类 号：R781.9[医药卫生—口腔医学] R943[医药卫生—临床医学]