放射治疗后颈动脉狭窄的分子机制研究进展  

Advances in molecular mechanisms of carotid artery stenosis after radiotherapy

作　　者：张潇 崔晟岩 徐然 李家耀 焦力群[2] 王韬 Zhang Xiao;Cui Shengyan;Xu Ran;Li Jiayao;Jiao Liqun;Wang Tao(Department of Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;不详)

机构地区：[1]首都医科大学宣武医院神经外科,北京100053 [2]首都医科大学宣武医院介入放射科,北京100053

出　　处：《中国脑血管病杂志》2024年第9期632-637,共6页Chinese Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金青年科学基金项目(82301468)。

摘　　要：近年来,放射治疗在头颈部肿瘤治疗中的广泛应用,显著提高了患者的生存期。然而,放射治疗引发的颈动脉狭窄问题日益受到关注。放射治疗后颈动脉狭窄具有多发、长节段及病变不稳定等特点,传统治疗手段难以应对。作者系统性总结了放射治疗引发颈动脉狭窄的病理特征及机制,探讨了内皮细胞、平滑肌细胞和滋养血管损伤在其中的作用,并对其未来研究方向及防治策略进行了展望。In recent years,radiation therapy has become a cornerstone in the treatment of head and neck tumors,significantly improving patient survival rates.However,the issue of radiation-induced carotid artery stenosis has garnered increasing attention.Characterized by multiple,long-segment,and unstable lesions,radiation-induced carotid stenosis presents unique challenges that traditional therapeutic approaches struggle to address.This review systematically summarized the pathological features and underlying mechanisms of radiation-induced carotid stenosis,with a focus on the roles of endothelial cells,smooth muscle cells,and vasa vasorum damage.Future research directions and preventive strategies are also discussed.

关 键 词：颈动脉狭窄 放射治疗 分子机制 综述 

分 类 号：R743[医药卫生—神经病学与精神病学]