肠道菌群影响脑淀粉样血管病中淀粉样蛋白沉积的潜在机制探讨  

The potential mechanism of intestinal microbiota affecting amyloid deposition in cerebral amyloid angiopathy

作　　者：张丹[1] 叶晓东 黄珊珊[1] 朱遂强[1] Zhang Dan;Ye Xiaodong;Huang Shanshan;Zhu Suiqiang(Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院神经科,武汉430030

出　　处：《中国脑血管病杂志》2024年第9期643-648,F0003,共7页Chinese Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金(82401567)。

摘　　要：脑淀粉样血管病(CAA)是一种以淀粉样蛋白β(Aβ)进行性沉积于皮质、皮质下及软脑膜小动脉为主要病理特点的脑小血管病,在老龄化人群中多见,常以反复脑叶出血、认知障碍为特征性临床表现。近年来,肠道菌群多样性及其相关产物已被报道可通过神经炎症、破坏血-脑屏障等多种途径参与中枢神经系统疾病的致病过程。而肠道菌群在CAA中的潜在机制目前并不明晰。已有研究表明,肠道菌群紊乱可通过诱发颅内Aβ产生和聚集、血-脑屏障渗漏、Aβ转运受体失衡引起血管壁改变,并伴随神经炎症机制,可能一定程度推动了CAA的发生和发展。作者对肠道菌群影响CAA中淀粉样蛋白沉积的可能机制进行综述,以期为CAA潜在临床治疗靶点的探索提供理论参考。Cerebral amyloid angiopathy(CAA)is one of the cerebral small vessel diseases in which amyloid-βis deposited in the cortical,subcortical and leptomeningal arterioles.The disease is commonly encountered in the elderly,characterized by recurrent lobar hemorrhage and cognitive dysfunction.In recent years,the diversity of intestinal microbiota and its products have been reported to be involved in the pathogenic process of central nervous system diseases through various pathways such as neuroinflammation and blood brain barrier leakage.However,the underlying mechanism of intestinal microbiota in CAA is not clear.It has been reported that intestinal microbiota disorder can induce intracranial Aβproduction and aggregation,blood-brain barrier leakage,and Aβtransport receptor imbalance,and then damage in blood vessels,accompanied by neuroinflammatory mechanisms.The authors reviewed the potential mechanism of intestinal microbiota involved in amyloid deposition to provide a theoretical reference for the exploration of potential clinical therapeutic targets for CAA.

关 键 词：脑淀粉样血管病 肠道菌群 淀粉样蛋白β 综述 

分 类 号：R743[医药卫生—神经病学与精神病学]