肥胖与白内障的因果关系:一项孟德尔随机化研究  

The Causal Relationship Between Obesity and Cataract:A Mendelian Randomization Study

作　　者：曹雯媗 郭晓勤[1] 杨剑英[1] 罗悦 钟莉 陈亦霞 李言泷 吴宁玲[1] CAO Wenxuan;GUO Xiaoqin;YANG Jianying;LUO Yue;ZHONG Li;CHEN Yixia;LI Yan-long;WU Ningling(Eye Hospital,China Academy of Chinese Medical Sciences,Beijing 100040,China)

机构地区：[1]中国中医科学院眼科医院,北京100040 [2]江苏省镇江市中医院,镇江212008

出　　处：《中国中医眼科杂志》2024年第10期929-935,共7页China Journal of Chinese Ophthalmology

基　　金：中国中医科学院科技创新工程重大攻关项目(CI2021A02612)。

摘　　要：目的 使用两样本孟德尔随机化(MR)方法探索肥胖指标(体质量指数、腰围、髋围)与白内障是否存在因果关联。方法 使用IEU Open GWAS数据库体质量指数、腰围、髋围和白内障全基因组关联研究的汇总统计数据,使用单核苷酸多态性(SNP)作为因果推断的工具变量,进行两样本MR分析。采用逆方差加权法(IVW)评估体质量指数、腰围、髋围与白内障的是否存在因果关联,同时采用MR-Egger回归法、加权中位数法(WME)、异质性检验及敏感性分析对结果进行补充分析。结果 (1)筛选结果:暴露因素中,体质量指数共筛选出458个SNP,腰围共筛选出374个SNP,髋围共筛选出398个SNP;结局因素白内障筛选出459个SNP。(2)体质量指数:体质量指数是白内障发生的强相关因素,有统计学意义[OR=1.189,95%CI(1.135,1.247),F=52.452,P=0.000]。MR-Egger回归法显示不存在水平多效性(P>0.05),且体质量指数与白内障散点图斜率为正,表明二者存在因果关系。(3)腰围:腰围是白内障发生的强相关因素,有统计学意义[OR=1.221,95%CI(1.145,1.303),F=36.776,P=0.000]。MR-Egger回归法显示不存在水平多效性(P>0.05),且腰围与白内障存在因果关系散点图斜率为正,表明二者存在因果关系。(4)髋围:髋围是白内障发生的强相关因素,有统计学意义[OR=1.119,95%CI(1.061,1.180),F=16.850,P=0.000]。MR-Egger回归法显示不存在水平多效性(P>0.05),且髋围与白内障存在因果关系散点图斜率为正,表明二者存在因果关系。结论 体质量指数、腰围、髋围均与白内障的发生存在因果关系。其中,体质量指数的增高对白内障发生的影响更为明显。OBJECTIVE To explore the causal relationship between obesity indices(body mass index,waist circumference,and hip circumference)and cataract using a two-sample Mendelian randomization(MR)approach.METHODS Summary statistics for body mass index,waist circumference,hip circumference,and cataract from GWAS were obtained from the IEU Open GWAS database.Single nucleotide polymorphisms(SNPs)were employed as instrumental variables for causal inference,and two-sample MR analyses were conducted.The inverse variance weighted(IVW)method was used to evaluate the causal associations between body mass index,waist circumference,hip circumference,and cataract.Additionally,MR-Egger regression,the weighted median estimator(WME),heterogeneity tests,and sensitivity analyses were conducted to supplement the findings.RESULTS(1)Selection results:For the exposure variables,458 SNPs were selected for body mass index,374 SNPs for waist circumference,and 398 SNPs for hip circumference.For the outcome variable,459 SNPs were selected for cataract.(2)Body mass index:Body mass index was found to be a significant causal factor for cataract[OR=1.189,95%CI(1.135,1.247),F=52.452,P=0.000].MR-Egger regression showed no horizontal pleiotropy(P>0.05),and the slope of the scatter plot for body mass index and cataract was positive,indicating a causal relationship between them.(3)Waist circumference:Waist circumference was also identified as a significant causal factor for cataract[OR=1.221,95%CI(1.145,1.303),F=36.776,P=0.000].MR-Egger regression revealed no horizontal pleiotropy(P>0.05),with a positive slope in the scatter plot for waist circumference and cataract,further supporting a causal relationship.(4)Hip circumference:Hip circumference was a significant causal factor for cataract as well[OR=1.119,95%CI(1.061,1.180),F=16.850,P=0.000].MR-Egger regression indicated no horizontal pleiotropy(P>0.05),and the positive slope of the scatter plot for hip circumference and cataract indicated a causal relationship between the two.CONCLUSIONS There is a causal

关 键 词：孟德尔随机化 白内障 肥胖 体质量指数 腰围 髋围 

分 类 号：R776.1[医药卫生—眼科]