Characterization of immunogenic cell death-related genes predicting prognosis in colon adenocarcinoma  

作　　者：Jie Chen Hong-Yi Zhou Fu-Yi Xie 

机构地区：[1]Laboratory Centre,Li Huili Hospital,Ningbo Medical Centre,Ningbo 315040,China [2]Department of Anorectal Surgery,Li Huili Hospital,Ningbo Medical Centre,Ningbo 315040,China

出　　处：《Medical Data Mining》2024年第4期19-27,共9页TMR医学数据挖掘

摘　　要：Background:Colon adenocarcinoma(COAD)is a gastrointestinal malignancy with a high mortality rate.Studies have confirmed the role of immunogenic cell death(ICD)in different cancer types.However,there is a lack of research on ICD-related genes(ICD-RGs)in COAD.This study aimed to examine the impact of ICD-RGs on COAD and their interaction with the immune microenvironment.Methods:Using data from The Cancer Genome Atlas and Gene Expression Omnibus databases,we identified 107 ICD-RGs in COAD.Using a one-way Cox regression analysis,we examined the relationship between these ICD-RGs and overall survival in COAD.Results:Following the regression analyses,we identified 14 overall survival-related genes.Furthermore,we examined the predictive impact of the ICD-RGs using the least absolute shrinkage and selection operator regression analysis and developed a nine-genes prognostic model.The Cancer Genome Atlas and Gene Expression Omnibus datasets were used for training and validation.Kaplan-Meier analysis was used to confirm that the high-risk group had a lower survival rate than the low-risk group.Finally,following a multifactorial analysis,we created a prognostic nomogram that integrated clinical data and risk scores.Conclusions:The nine-genes model exhibits robust stability and can provide valuable insights for guiding the development of tumor immunotherapy strategies and personalized drug selection for patients with COAD.

关 键 词：colon adenocarcinoma least absolute shrinkage and selection operator PROGNOSIS immunogenic cell death-related genes 

分 类 号：R73[医药卫生—肿瘤]