抗癫痫发作药物致畸的临床试验和动物实验研究进展  

Recent advance in clinical trials and animal experiments regarding teratogenic effects of anti-seizure medication

作　　者：洪秋蕾 段亦非 沙雷皓 夏逸林 唐钰莎 陈蕾[1] Hong Qiulei;Duan Yifei;Sha Leihao;Xia Yilin;Tang Yusha;Chen Lei(Department of Neurology,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院神经内科,成都610041

出　　处：《中华神经医学杂志》2024年第9期940-946,共7页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金(12026607)。

摘　　要：育龄期女性癫痫患者约占所有癫痫患者的40%,妊娠期女性癫痫患者的疾病负担高出普通癫痫患者的5倍,且死胎率和畸胎率是普通育龄期女性的5倍。因此,全面总结妊娠期女性癫痫患者使用抗癫痫发作药物(ASMs)相关研究现状,对于规范育龄期女性癫痫患者的全程管理、降低疾病负担尤为重要。本文全面总结了近年来ASMs致畸相关研究进展,总结了妊娠期使用ASMs对后代健康的影响和对育龄期女性癫痫患者临床管理的相关建议,以期为妊娠期女性癫痫患者的安全用药提供参考。Pregnant women account for 40%of all epilepsy patients,and the economic burden of pregnant women with epilepsy is 5 times higher than that of non-pregnant patients.Additionally,the rates of stillbirth and congenital malformations in pregnant women with epilepsy are 5 times greater than those in normal pregnant women.Therefore,it is crucial to comprehensively review and summarize the management of pregnant women with epilepsy to reduce the burden of the disease.This study provides a thorough review on teratogenic effects of anti-seizure medications(ASMs)used during pregnancy,and summarizes the effects of ASMs on health of offspring and offers clinical management recommendations for pregnant women with epilepsy,aiming to provide guidance for safe use of medications during pregnancy.

关 键 词：癫痫 抗癫痫发作药物 妊娠 用药安全 致畸 

分 类 号：R742.1[医药卫生—神经病学与精神病学]