铁死亡在非小细胞肺癌机制特性及免疫微环境中作用的研究进展  

Research progress of ferroptosis in the mechanism and immune microenvironment of non⁃small cell lung cancer

作　　者：郭晓阳 曾凡 郑楷 李标 GUO Xiaoyang¹;ZENG Fan;ZHENG Kai;LI Biao(Graduate School,Hainan Medical College,Haikou 571199,China;The Second Affiliated Hospital of Hainan Medical University,Haikou 570216,China;Thoracic Surgeons Branch of Hainan Medical Association,Haikou 571924,China)

机构地区：[1]海南医学院,海南海口571199 [2]海南医学院第二附属医院,海南海口570216 [3]海南省医师协会胸外科医师分会,海南海口571924

出　　处：《海南医学院学报》2024年第19期1507-1513,共7页Journal of Hainan Medical University

基　　金：2022年海南省自然科学基金项目(822RC843)。

摘　　要：铁死亡(ferroptosis)是近年来新发现的、以氧化还原途径为特征的细胞死亡方式。它在机制特性以及调控代谢等方面都与以往的细胞凋亡、细胞坏死和自噬等经典途径不同。随着对非小细胞肺癌(NSCLC)肿瘤微环境和铁代谢异常的深入研究,铁死亡引起了学术界的广泛关注。本文重点介绍了铁死亡在NSCLC发展中的调控机制、铁死亡对NSCLC细胞生物学特性的影响以及铁死亡在免疫微环境中的作用,深入探讨铁死亡作为临床治疗靶点的可能性,为NSCLC治疗策略的发展提供新思路。Ferroptosis is a newly discovered cell death pattern characterized by pathway of reduction-oxidation in recent years.It is different from the classical pathways such as apoptosis,necrosis and autophagy in its mechanism and regulation of metabolism.With the in⁃depth study of tumor microenvironment and iron metabolism abnormalities in non⁃small cell lung cancer(NSCLC),ferroptosis has attracted extensive attention in the academic community.This paper focuses on the regulatory mechanism of ferrop⁃tosis in the development of NSCLC,the effects of ferroptosis on the biological characteristics of NSCLC cells,and the role of fer⁃roptosis in the immune microenvironment,aiming to further explore the possibility of ferroptosis as a clinical therapeutic target and provide new ideas for the development of therapeutic strategies for NSCLC.

关 键 词：铁死亡 非小细胞肺癌 肿瘤免疫 细胞生物学特性 调控机制 

分 类 号：R734.2[医药卫生—肿瘤]