偏头痛患者脑灰质核团铁沉积与认知改变的关系的特征定量磁化率图研究  

Quantitative susceptibility mapping(QSM)study of iron metabolism abnormalities in deep brain nuclei of migraine patients and their relationship to cognitive changes

作　　者：徐隆基 杨静[2,3] 任福欣 李茜 王晶 刘雨茜 张文静 高飞 赵斌[2] XU Longji;YANG Jing;REN Fuxin;LI Xi;WANG Jing;LIU Yuxi;ZHANG Wenjing;GAO Fei;ZHAO Bin(Shandong University,Jinan 250012,China;Department of Medical Imaging,Shandong Provincial Hospital,Jinan 250021,China;Department of Medical Imaging,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China)

机构地区：[1]山东大学,山东济南250012 [2]山东省立医院医学影像科,山东济南250021 [3]山东第一医科大学附属省立医院医学影像科,山东济南250021

出　　处：《医学影像学杂志》2024年第9期1-4,共4页Journal of Medical Imaging

基　　金：泰山学者建设工程(编号:tstp20240525);山东省自然科学基金(编号:ZR2021MH030);山东第一医科大学学术提升计划(编号:2019QL023)。

摘　　要：目的探讨定量磁化率图(QSM)对偏头痛患者大脑深部核团中的铁代谢改变及其与认知和情绪改变的关系。方法选取38例偏头痛患者(MIG组)和41例健康查体者(HCs组),使用磁共振序列QSM观察NAC、DN、EXA、SNc、RN、SNr、PBP、HTH及STH铁沉积变化,并观察其与认知、情绪及偏头痛特征的相关性。结果MIG组表现出多种认知功能的损害,MIG组的NAC(P=0.032)、EXA(P=0.035)、SNc(P=0.019)、RN(P=0.014)和SNr(P=0.010)的QSM值均高于HCs组。此外,NAC(r=0.439,P=0.008)、EXA(r=0.512,P=0.002)的QSM值与TMT-A评分呈正相关;RN(r=0.448,P<0.007)的QSM值与MSQ评分呈正相关;SNr(r=0.448,P<0.007)的QSM值与PHQ9评分呈正相关。结论定量磁化率图(QSM)为偏头痛患者认知功能改变的分析提供了参考。Objective To investigate the changes in iron metabolism in deep brain nuclei of migraine patients using quantitative magnetic susceptibility mapping(QSM)and their relationship with cognitive and emotional changes.Methods This study included 38 migraine patients(MIG)and 41 healthy controls(HCs).Using magnetic resonance sequences QSM,we investigated the changes in iron deposition in the nucleus accumbens(NAC),cerebellar dentate nucleus(DN),extended amygdala(EXA),substantia nigra pars compacta(SNc),red nucleus(RN),substantia nigra reticular region(SNr),peribrachial pigment nuclei(PBP),hypothalamus(HTH),and subthalamic nucleus(STH),as well as observed their correlation with cognitive,emotional,and migraine characteristics.Results The MIG group exhibited various cognitive impairments.The QSM values of NAC(P=0.032),EXA(P=0.035),SNc(P=0.019),RN(P=0.014),and SNr(P=0.010)in the MIG group were higher than those in the HC group.In addition,the QSM values of NAC(r=0.439,P=0.008)and EXA(r=0.512,P=0.002)were positively correlated with the TMT-A score.The QSM value of RN(r=0.448,P<0.007)was positively correlated with the MSQ score.The QSM value of SNr(r=0.448,P<0.007)was positively correlated with PHQ9 score.Conclusion This study provides a new perspective for analyzing cognitive and emotional changes in migraine patients.

关 键 词：偏头痛 定量磁化率图 铁沉积 认知 焦虑 磁共振成像 

分 类 号：R747.2[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]