分析舒眠胶囊联合草酸艾司西酞普兰治疗焦虑症伴睡眠障碍的效果及对睡眠质量的影响  

To Analyze the Effect of Shumian Capsule Combined with Escitalopram Oxalate in the Treatment of Anxiety and Sleep Disorders and Its Influence on Sleep Quality

作　　者：庄成桂[1] 陈坤城[1] 徐诗原 陈欣 ZHUANG Chenggui;CHEN Kuncheng;XU Shiyuan;CHEN Xin(The Third Hospital of Quanzhou,Quanzhou 362000,China)

机构地区：[1]福建省泉州市第三医院,泉州362000

出　　处：《世界睡眠医学杂志》2024年第7期1436-1439,共4页World Journal of Sleep Medicine

摘　　要：目的:分析舒眠胶囊联合草酸艾司西酞普兰治疗焦虑症伴睡眠障碍的效果及对睡眠质量的影响。方法:选取2021年9月至2023年8月福建省泉州市第三医院收治的焦虑症合并睡眠障碍患者92例作为研究对象,按照随机数字表法分为对照组和观察组,每组46例。对照组给予佐匹克隆联合草酸艾司西酞普兰治疗,观察组给予舒眠胶囊联合草酸艾司西酞普兰治疗。采用匹兹堡睡眠质量指数(PSQI)比较2组患者干预前后睡眠质量的变化,采用汉密尔顿焦虑量表(HAMA)比较2组患者干预前后焦虑状态的改善效果,采用多导睡眠监测仪监测患者的总睡眠时间(TST)、睡眠潜伏期(SL)、睡眠效率(SE)、非快动眼睡眠(REM)N1期、非REM N2期、慢波睡眠(SWS)、快动眼睡眠(REM)、REM潜伏期、微觉醒(RERA)次数,并比较2组患者的治疗有效率。结果:治疗后,观察组总有效率显著高于对照组,观察组PSQI评分、HAMA评分显著低于对照组,观察组睡眠时间(TST)、睡眠效率(SE)、非快动眼睡眠(REM)N1期、非REM N2期、慢波睡眠(SWS)、快动眼睡眠(REM)评分显著高于对照组,观察组睡眠潜伏期(SL)、REM潜伏期、微觉醒(RERA)次数评分显著低于对照组,差异均有统计学意义(均P<0.05)。结论:舒眠胶囊联合草酸艾司西酞普兰治疗焦虑症伴睡眠障碍的效果显著,能有效提高患者的睡眠质量并改善焦虑症状,值得推广应用。Objective:To analyze the effect of Shumian capsule combined with Escitalopram oxalate in the treatment of anxiety disorder accompanied by sleep disorders and its influence on sleep quality.Methods:A total of 92 patients with anxiety and sleep disorders admitted to the Third Hospital of Quanzhou City,Fujian Province from September 2021 to August 2023 were selected as research objects,and were divided into control group and observation group according to random number table method,with 46 cases in each group.The control group was given Zopiclone combined with escitalopram oxalate,and the observation group was given Shumian capsule combined with Escitalopram oxalate.Pittsburgh Sleep Quality Index(PSQI)was used to compare the changes of sleep quality before and after intervention between the two groups,and Hamilton Anxiety Scale(HAMA)was used to compare the improvement effect of anxiety state between the two groups before and after intervention.Total sleep time(TST),sleep latency(SL),sleep efficiency(SE),non-rapid eye movement(REM)phase N1,non-REM N2,slow wave sleep(SWS),rapid eye movement sleep(REM),REM latency,and the number of microawakenations(RERA)were monitored by polysleep monitor.The treatment efficiency of the two groups was compared.Results:After treatment,the total effective rate of the observation group was significantly higher than that of the control group,the PSQI scores and HAMA scores of the observation group were significantly lower than those of the control group,and the scores of sleep time(TST),sleep efficiency(SE),non-rapid eye movement sleep(REM)N1,non-REM N2,slow wave sleep(SWS)and rapid eye movement sleep(REM)in the observation group were significantly higher than those of the control group.The sleep latency(SL),REM latency and RERA scores of the observation group were significantly lower than those of the control group,the difference between the two groups was statistically significant(P<0.05).Conclusion:Shumian capsule combined with Escitalopram oxalate has a significant effect on the treat

关 键 词：舒眠胶囊 佐匹克隆 草酸艾司西酞普兰 焦虑症伴睡眠障碍 疗效 睡眠质量 焦虑症状 多导睡眠监测参数 

分 类 号：R749.72[医药卫生—神经病学与精神病学] R338.63[医药卫生—临床医学]