肺腺癌伴区域淋巴结转移患者驱动基因突变情况及与临床特征的关系  

Driver gene mutations in patients with lung adenocarcinoma complicated with regional lymph node metastasis and their relationship with clinical features

作　　者：王炎 靳红领 董嘉兴 WANG Yan;JIN Hongling;DONG Jiaxing(Department of Thoracic Surgery,Nanshi Hospital of Nanyang,Nanyang 473000,He’nan,China)

机构地区：[1]南阳南石医院胸外科,河南南阳4730000

出　　处：《癌症进展》2024年第17期1960-1964,共5页Oncology Progress

基　　金：河南省医学科技攻关计划(联合共建)项目(LHGJ20191473)。

摘　　要：目的探讨肺腺癌伴区域淋巴结转移患者驱动基因突变情况及与临床特征的关系。方法选取100例肺腺癌伴区域淋巴结转移患者,采用聚合酶链反应(PCR)检测表皮生长因子受体(EGFR)、间变性淋巴瘤激酶(ALK)、ROS原癌基因1受体酪氨酸激酶(ROS1)及RET基因突变情况。分析肺腺癌伴区域淋巴结转移患者驱动基因突变情况,并比较不同临床特征肺腺癌伴区域淋巴结转移患者驱动基因突变情况。结果100例肺腺癌伴区域淋巴结转移患者基因检测结果显示,单基因突变中,EGFR突变44例(44%),ALK突变19例(19%),RET突变6例(6%),ROS1突变3例(3%)。不同性别、吸烟史、N分期肺腺癌伴区域淋巴结转移患者EGFR突变情况比较,差异均有统计学意义(P﹤0.05)。不同性别、N分期肺腺癌伴区域淋巴结转移患者ALK突变情况比较,差异均有统计学意义(P﹤0.05)。不同性别、吸烟史、分化程度、N分期肺腺癌伴区域淋巴结转移患者ROS1、RET突变情况比较,差异均无统计学意义(P﹥0.05)。结论肺腺癌伴区域淋巴结转移患者存在EGFR、ALK、ROS1及RET基因突变,以EGFR基因突变为主,EGFR突变患者淋巴结转移风险较小,ALK基因突变患者可能存在更高的淋巴结转移风险。Objective To investigate the driver gene mutations in patients with lung adenocarcinoma with regional lymph node metastasis and their relationship with clinical features.Method A total of 100 patients with lung adenocarcinoma complicated with regional lymph node metastasis were selected,and the mutation of epidermal growth factor receptor(EGFR),anaplastic lymphoma kinase(ALK),ROS proto-oncogene 1,receptor tyrosine kinase(ROS1)and RET gene were detected by polymerase chain reaction(PCR).The driver gene mutations in patients with lung adenocarcinoma complicated with regional lymph node metastasis were analyzed,and the driver gene mutations in patients with different clinical features of lung adenocarcinoma complicated with regional lymph node metastasis were compared.Result The genetic testing results of 100 patients with lung adenocarcinoma complicated with regional lymph node metastasis showed that among single gene mutation,44 cases(44%)had EGFR mutations,19 cases(19%)had ALK mutations,6 cases(6%)had RET mutations,and 3 cases(3%)had ROS1 mutations.There were significant differences in EGFR mutation among patients with lung adenocarcinoma complicated with regional lymph node metastasis of different gender,smoking history and N stage(P<0.05).There were significant differences in ALK mutation among patients with adenocarcinoma complicated with regional lymph node metastasis of different gender and N stage(P<0.05).There were no significant differences in ROS1 and RET mutations among patients with lung adenocarcinoma complicated with regional lymph node metastasis of different gender,smoking history,differentiation degree and N stage(P>0.05).Conclusion Patients with lung adenocarcinoma complicated with regional lymph node metastasis have EGFR,ALK,ROS1 and RET gene mutations,with EGFR being the main mutated gene.EGFR mutation patients have a lower risk of lymph node metastasis,and ALK gene mutation patients may have a higher risk of lymph node metastasis.

关 键 词：肺腺癌 区域淋巴结转移 临床特征 

分 类 号：R734.2[医药卫生—肿瘤]