艾司西酞普兰联合支持性心理治疗在抑郁障碍中的效果分析  

Analysis on Effect of Escitalopram Combined with Supportive Psychotherapy for Depressive Disorders

作　　者：李哲[1] 武文煜[1] 贾荣 曾淑娥[1] Li Zhe;Wu Wenyu;Jia Rong;Zeng Shue(Mental Hospital of Yunnan Province,Kunming 650000,Yunnan Province,China)

机构地区：[1]云南省精神病医院,云南昆明650000

出　　处：《中国社区医师》2024年第23期32-34,共3页Chinese Community Doctors

摘　　要：目的:探讨艾司西酞普兰联合支持性心理治疗在抑郁障碍中的效果。方法:选取2021年1月—2022年1月在云南省精神病医院住院治疗的60例抑郁障碍患者进行研究,基于随机双盲法分为对照组和观察组,各30例。两组均应用艾司西酞普兰治疗,观察组在此基础上进行支持性心理治疗。比较两组患者抑郁、日常行为能力及临床疗效情况。结果:两组患者治疗4周、8周后汉密尔顿抑郁量表(HAMD-24)、抑郁自评量表(SDS)评分均低于治疗前,且治疗8周后HAMD-24、SDS评分低于治疗4周后,差异有统计学意义(P<0.05);观察组患者治疗4周、8周后HAMD-24、SDS评分低于对照组,差异有统计学意义(P<0.05)。两组患者治疗4周、8周后日常生活能力量表(ADL)评分均高于治疗前,且治疗8周后ADL评分高于治疗4周后,差异有统计学意义(P<0.05);观察组患者治疗4周、8周后ADL评分高于对照组,差异有统计学意义(P<0.05)。两组总有效率比较,差异无统计学意义(P>0.05)。结论:艾司西酞普兰联合支持性心理治疗对抑郁障碍患者有明显疗效,效果优于单用艾司西酞普兰。Objective:To investigate the effect of escitalopram combined with supportive psychotherapy for depressive disorder.Methods:A total of 60 patients with depressive disorder who were hospitalized in Mental Hospital of Yunnan Province from January 2021 to January 2022 were selected for the study.They were divided into control group and observation group according to random double blind method,with 30 cases in each group.Both groups were treated with escitalopram.On this basis,the observation group received supportive psychotherapy.The depression,daily behavior ability and clinical efficacy of the two groups were compared.Results:After 4 weeks and 8 weeks of treatment,the scores of Hamilton Depression Rating Scale(HAMD-24)and Self-Rating Depression Scale(SDS)in two groups were lower than those before treatment,and the scores of HAMD-24 and SDS after 8 weeks of treatment were lower than those after 4 weeks of treatment,with a statistically significant difference(P<0.05).After 4 weeks and 8 weeks of treatment,the scores of HAMD-24 and SDS in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).After 4 weeks and 8 weeks of treatment,the scores of activities of daily living(ADL)in the two groups were higher than those before treatment,and the ADL scores after 8 weeks of treatment were higher than those after 4 weeks of treatment,with a statistically significant difference(P<0.05).After 4 weeks and 8 weeks of treatment,the ADL scores in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total effective rate between the two groups(P>0.05).Conclusion:Escitalopram combined with supportive psychotherapy has obvious efficacy in patients with depressive disorders,and the effect is better than escitalopram alone.

关 键 词：抑郁障碍 艾司西酞普兰 支持性心理治疗 

分 类 号：R749.4[医药卫生—神经病学与精神病学]