中医基础理论与干细胞理论的关系  

Relationship Between Basic Theory of Traditional Chinese Medicine and Stem Cell Theory

作　　者：孟婉婷 赵猛 国海东[1] MENG Wanting;ZHAO Meng;GUO Haidong(School of Integrative Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai Medical College of Fudan University,Shanghai 200032,China)

机构地区：[1]上海中医药大学中西医结合学院,上海201203 [2]复旦大学上海医学院,上海200032

出　　处：《世界中医药》2024年第17期2627-2630,2635,共5页World Chinese Medicine

基　　金：国家自然科学基金项目(82174120,81673729)——基于外泌体miR-146a/CXCR4介导的内源性干细胞动员探讨电针减轻心肌缺血再灌注损伤的机制;补气活血中药优化微环境在诱导多功能干细胞移植治疗心肌梗死中的作用机制;上海市优秀学术带头人计划项目(22XD1423400)——益气活血补肾方通过SDF-1/CXCR4信号通路动员内源性干细胞促进心肌缺血损伤后修复的作用及机制;上海市自然科学基金项目(21ZR1463100)——基于外泌体miR-146a介导的内源性干细胞动员探讨加味桃红四物汤促进心肌缺血损伤修复的作用机制。

摘　　要：中医是以精气学说、藏象学说、经络学说为中心的系统性整体性医学,整体观与辨证论治贯穿于中医理论的始终。而整体观源于古代哲学思想,是通过宏观思辨的模式,对机体生理功能和病理变化的整体认识。干细胞是指存在于胚胎直至成体的具有增殖及多分化潜能的原始细胞。干细胞理论在中医理论中的归属是以肾精为主,脏腑经络等共同参与构成的多方面、多层次体系。挖掘干细胞理论在中医基础理论中的内涵和本质,是实现中医现代化和国际化的重要途径,对于理解和创新中医理论具有重要的意义,也为中西医结合研究提供一种思路和参考。Traditional Chinese medicine(TCM)is a holistic medical system centered around essence-qi theory,visceral manifestation theory,and meridian and collateral theory.The holistic perspective and treatment based on syndrome differentiation are fundamental to TCM theoretical framework.This holistic view originates from ancient philosophical thought,emphasizing a comprehensive understanding of the body′s physiological functions and pathological changes through macroscopic dialectical thought.Stem cells are primitive cells with proliferation and multi-differentiation potential existing from the embryonic stage to adulthood.The attribution of stem cell theory within TCM is primarily centered on kidney essence,forming a multifaceted and multi-level system that also involves various organs,meridians,and collaterals.Exploring the implications and essence of stem cell theory within the foundational theories of TCM is a crucial pathway for the modernization and internationalization of TCM.This exploration is significant for understanding and innovating TCM theory and provides a reference point for integrative research combining TCM and Western medicine.

关 键 词：干细胞 中医理论 精气学说 藏象学说 经络学说 整体观 辨证论治 中西医结合 

分 类 号：R223[医药卫生—中医基础理论]