人体成分与跟骨骨密度因果关联:一项孟德尔随机化研究  

Causal relationship between body composition and calcaneal bone mineral density:a Mendelian randomization analysis

作　　者：宋继东[1] 刘暾 张心毅 赵家鑫 王伟[1] SONG Jidong;LIU Tun;ZHANG Xinyi;ZHAO Jiaxin;WANG Wei(Department of Orthopedics,Second Affiliated Hospital of Xi′an Jiaotong University,Xi′an 710003,China)

机构地区：[1]西安交通大学第二附属医院骨科,西安710003

出　　处：《山西医科大学学报》2024年第8期1055-1061,共7页Journal of Shanxi Medical University

基　　金：国家自然科学基金青年项目(82102566)。

摘　　要：目的采用孟德尔随机化方法研究人体成分与跟骨骨密度的因果关系。方法利用全基因关联分析数据,暴露因素为全身脂肪量、全身水分量和去脂体质量,结局变量为跟骨骨密度。采用IVW法、MR-Egger法、加权中位数法、简单模式法、加权模式法进行孟德尔随机化分析,并行异质性、敏感性、多效性分析以检验结果可靠性。结果IVW法显示全身脂肪量与跟骨骨密度存在正向因果关系(β=1.10,95%CI 1.05~1.15,P<0.001),MR-Egger法、加权中位数法、加权模式法与IVW法结果一致,敏感性分析显示单核苷酸多态性无异质性和水平多效性;IVW法显示全身水分量与跟骨骨密度因果关系无统计学意义(β=0.96,95%CI 0.91~1.02,P>0.05);IVW法显示去脂体质量与跟骨骨密度之间因果关系无统计学意义(β=0.97,95%CI 0.91~1.03,P>0.05)。结论人体全身脂肪量与跟骨骨密度存在正向因果关系。Objective To investigate the causal relationship between body composition and calcaneal BMD by Mendelian randomization methods.Methods The genome-wide association study data were used.The exposure factors were whole body fat mass,whole body water mass,and whole body fat free mass.The outcome variable was calcaneus BMD.IVW method,MR-Egger method,weighted median method,simple mode method and weighted mode method were used for Mendelian randomization analysis.Heterogeneity,sensitivity and pleiotropy were tested to evaluate the reliability.Results The IVW method showed a positive causal relationship between whole body fat mass and calcaneus BMD(β=1.10,95%CI 1.05-1.15,P<0.001).The results of MR-Egger method,weighted median method and weighted mode method were consistent with that of IVW method.Sensitivity analysis results showed no heterogeneity or horizontal pleiotropy of single nucleotide polymorphisms(SNP).IVW method showed no significant causal relationship between whole body water mass and calcaneus BMD(β=0.96,95%CI 0.91-1.02,P>0.05).IVW method showed no significant causal relationship between whole body fat free mass and calcaneus BMD(β=0.97,95%CI 0.91-1.03,P>0.05).Conclusion There is a positive causal relationship between whole body fat mass and calcaneal bone mineral density.

关 键 词：人体成分 骨质疏松 全身脂肪量 跟骨骨密度 孟德尔随机化 全基因组关联分析 

分 类 号：R681[医药卫生—骨科学]