A型肉毒杆菌毒素在瘢痕防治中的应用  

Botulinum Toxin Type A in Scar Prevention and Treatment

作　　者：刘婷 马寒 LIU Ting;MA Han(Department of Dermatology,The Fifth Affiliated Hospital,Sun Yat-sen University,Zhuhai 519000,China)

机构地区：[1]中山大学附属第五医院皮肤科,广东珠海519000

出　　处：《皮肤科学通报》2024年第4期379-384,390,共7页Dermatology Bulletin

基　　金：2021年广东省医师协会皮肤研究专项课题(20210202)。

摘　　要：近年来,A型肉毒杆菌毒素(botulinum toxin type A,BTXA)在瘢痕的治疗中引起了广泛的讨论和关注,本综述旨在讨论近5年以来国内外学者对BTXA在各类瘢痕防治中的应用及研究。其中,BTXA在术后瘢痕的应用最为普遍,术后早期、更高剂量的注射方法能达到更好的疗效。BTXA对瘢痕疙瘩、增生性瘢痕具一定的治疗潜力,联合其他治疗方法能达到更好的治疗效果,其最常与局部皮质类固醇注射联合,及与微针、二氧化碳点阵激光、光动力联合治疗。总体而言,BTXA对各类瘢痕的疗效良好,不良反应少,但作用机制尚不明确,仍需进一步研究。In recent years,botulinum toxin type A(BTXA)has garnered extensive discussion and attention in the treatment of scars.This review aims to discuss the application and research of BTXA in the prevention and treatment of various types of scars by domestic and international scholars over the past five years.Among them,BTXA is most commonly used for postoperative scars,with early postoperative and higher dosage injections achieving better efficacy.BTXA shows certain therapeutic potential for keloids and hypertrophic scars,and combining it with other treatments can achieve better outcomes.It is most often combined with local corticosteroid injections,microneedling,fractional carbon dioxide laser,and photodynamic therapy.Overall,BTXA demonstrates good efficacy for various types of scars with few adverse reactions,but its mechanism of action remains unclear and requires further research.

关 键 词：A型肉毒杆菌毒素 术后瘢痕 增生性瘢痕 联合治疗 

分 类 号：R739.5[医药卫生—肿瘤]