多西他赛联合卡培他滨对转移性乳腺癌患者ctDNA的影响  

Effect of Docetaxel Combined with Capecitabine on ctDNA in Patients with Metastatic Breast Cancer

作　　者：张军峰 刘秀宝 王国鹏 ZHANG Junfeng;LIU Xiubao;WANG Guopeng(Department of Oncology,Hebi People’s Hospital,Hebi,Henan 458030,China)

机构地区：[1]鹤壁市人民医院肿瘤内科,河南鹤壁458030

出　　处：《生物医学工程学进展》2024年第3期250-255,共6页Progress in Biomedical Engineering

基　　金：河南省医学科技攻关计划项目(项目编号:LHGJ20210884)。

摘　　要：目的探究多西他赛联合卡培他滨应用于转移性乳腺癌患者的效果及对循环肿瘤DNA(circulating tumor DNA,ctDNA)水平的影响。方法选取鹤壁市人民医院2021年10月至2023年10月的82例转移性乳腺癌患者,依据抽签法进行分组。对照组41例给予卡培他滨治疗,观察组41例增加多西他赛治疗,对比两组患者的疾病控制率,以及肿瘤标志物ctDNA、癌胚抗原(Carcinoembryonic Antigen,CEA)、糖类抗原153(Carbohydrate Antigen 153,CA153)的水平及不良反应。结果经过严格的统计分析,两组不良反应发生率无统计学意义(P>0.05);观察组的疾病控制率显著高于对照组,在CA153、CEA、ctDNA水平方面,观察组显著低于对照组,这一差异具有统计学上的显著性(P<0.05)。结论多西他赛联合卡培他滨对转移性乳腺癌患者进行治疗,可有效提高抗肿瘤效果,安全性高。Objective To investigate the effects of Docetaxel combined with capecitabine on circulating tumor DNA(ctDNA)levels in patients with metastatic breast cancer.Methods A total of 82 patients with metastatic breast cancer in Hebi People’s Hhospital from October 2021 to October 2023 were selected and divided into groups according to lottery method.Forty-one patients in the control group were given capecitabine treatment,and 41 patients in the observation group were given Docetaxel treatment on the basis of capecitabine treatment.The disease control rate and ctDNA,carcinoembryonic Antigen(CEA),carbohydrate Antigen 153(CA153)levels and adverse reactions.of the two groups were compared.Results After rigorous statistical analysis,the results showed that there was no statistical significance in the incidence of adverse reactions between the two groups(P>0.05).The disease control rate of the observation group was significantly higher than that of the control group.Meanwhile,the levels of CA153,CEA and ctDNA in the observation group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Docetaxel combined with capecitabine can effectively improve the antitumor effect of patients with metastatic breast cancer with high safety.

关 键 词：多西他赛 卡培他滨 转移性乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]