胃食管反流病样症状内镜阴性患者的研究进展  

Research progress in endoscopy-negative patients with symptoms similar to gastroesophageal reflux disease

作　　者：于琳琳[1] 刘曼 南玲 宋蕾[1] 王丹[2] YU Linlin;LIU Man;NAN Ling;SONG Lei;WANG Dan(Department of Interventional therapy,the First Hospital of Jilin University,Changchun 130021,China;Department of Gastroenterology,the First Hospital of Jilin University,Changchun 130021,China;Department of Anaesthesiology,the First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院介入治疗科,长春130021 [2]吉林大学第一医院胃肠内科,长春130021 [3]吉林大学第一医院麻醉科,长春130021

出　　处：《长春中医药大学学报》2024年第10期1176-1180,共5页Journal of Changchun University of Chinese Medicine

基　　金：吉林省自然科学基金(YDZJ202401182ZYTS)。

摘　　要：以胃食管反流病(GERD)样症状就诊且内镜下食管黏膜或结构阴性患者,临床诊断和治疗方案的选择存在明显的异质性,而且不同诊断分型之间食管动力及抗反流屏障功能的差异尚不清楚。随着功能性胃肠病罗马IV标准的颁布,具有典型GERD样症状且内镜阴性患者的诊断分型包括非糜烂性反流病(NERD)、反流高敏感(RH)和功能性烧心(FH)。针对不同诊断分型间的发病机制、病理生理改变等的研究进展进行总结,为临床上鉴别食管功能性疾病及筛选出真正的GERD提供新的思路。For patients with symptoms similar to gastroesophageal reflux disease(GERD)(GERD-like symptoms)and negative esophageal mucosa or structure under endoscopy,there is significant heterogeneity in the selection of clinical diagnosis and treatment plans,and the differences in esophageal motility and anti-reflux barrier function among different diagnostic types are still unclear.With the promulgation of the Rome IV standard for functional gastrointestinal diseases,the diagnostic types of endoscopynegative patients with typical GERD-like symptoms include non-erosive reflux disease(NERD),reflux hypersensitivity(RH)and functional heartburn(FH).This paper summarizes research progress in the pathogenesis and pathophysiological changes among different diagnostic types,providing new ideas for distinguishing functional esophageal diseases and screening out true GERD in clinical practice.

关 键 词：胃食管反流病 非糜烂性反流病 功能性烧心 反流高敏感 

分 类 号：R573[医药卫生—消化系统]