中医药治疗乳腺癌相关抑郁发展的机制研究进展  

Research progress on the use of Traditional Chinese Medicines to treat breast cancer-related depression and associated diseases

作　　者：彭梦薇 吴耀松[1] 刘高源 匡洛逸 罗紫龙 陈玉龙[1] 刘燕[1,2] PENG Mengwei;WU Yaosong;LIU Gaoyuan;KUANG Luoyi;LUO Zilong;CHEN Yulong;LIU Yan(Henan University of Traditional Chinese Medicine,College of Traditional Chinese Medicine(Zhongjing College),Key Laboratory of Signal Transmission of TCM Formulas,Zhengzhou 450046,China;Henan University of Traditional Chinese Medicine,Henan Provincial Collaborative Innovation Center for R&D of Henan Pharmaceutical Industry Chain,Zhengzhou 450046)

机构地区：[1]河南中医药大学,中医学院(仲景学院),河南省中医方证信号传导重点实验室,郑州450046 [2]河南中医药大学,河南省豫药全产业链研发协同创新中心,郑州450046

出　　处：《中国比较医学杂志》2024年第9期108-116,共9页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金项目(82104717);河南省科技攻关重点研发与推广专项(202102310493,232102310443);河南省特色骨干学科中医学学科建设项目(STG-ZYXKY-2020028);河南省科技攻关(192102310160)。

摘　　要：乳腺癌诊断与治疗过程中出现以抑郁为主的病理性情绪变化,临床上称之为乳腺癌相关抑郁。大量的流行病学和临床研究已证实乳腺癌相关抑郁病情复杂且治疗难度大、预后差。现有临床治法大多是乳腺癌术后化疗服用抗抑郁药物,将乳腺癌和抑郁症作为两个独立的疾病进行治疗,存在效率低、不良反应强等诸多缺陷。而中医药凭借其多成分同时调控多通路、多靶点显著优势,在防治乳腺癌相关抑郁的方面具有独特价值。本文主要是从神经系统紊乱、炎症免疫反应、肠道菌群失调等方面对乳腺癌相关抑郁机制,以及中医药的治疗机制进行综述,以期对中医药治疗乳腺癌相关抑郁临床应用和研究提供一定的参考。Pathological mood changes,mainly depression,occurring during the diagnosis and treatment of breast cancer are referred to as breast cancer-related depression(BCRD).Numerous epidemiological and clinical studies have confirmed that BCRD is a complex condition that is difficult to treat and has a poor prognosis.Most existing clinical treatments involve the use of postoperative chemotherapy for breast cancer,and antidepressant drugs,which treat breast cancer and depression as two independent diseases and have various disadvantages such as low efficiency and strong adverse reactions.Traditional Chinese Medicine(TCM)has a unique value in the prevention and treatment of BCRD via its ability to regulate multiple pathways and targets using multiple components at the same time.In this paper,we review the mechanism of BRCD and the therapeutic mechanisms of TCM from the aspects of neurological disorders,inflammatory immune response,and intestinal flora disorders,with a view to providing references for the clinical application and research of TCM in the treatment of BCRD.

关 键 词：乳腺癌相关抑郁 发病机制 中医药治疗 综述 

分 类 号：R-33[医药卫生]