冠心病痰瘀互结证中巨噬细胞代谢与免疫作用研究进展  

Research progress on macrophage metabolism and immune function in coronary heart disease with phlegm and blood stasis syndrome

作　　者：曹盼夏 彭紫凝 李剑 吴鸿[1] CAO Panxia;PENG Zining;LI Jian;WU Hong(the Second Clinical Medical College of Henan University of Traditional Chinese Medicine,Zhengzhou 450002,China;Zhengzhou People’s Hospital,Zhengzhou 450002;the First Clinical Medical College of Yunnan University of Chinese Medicine,Kunming 650000)

机构地区：[1]河南中医药大学第二临床医学院,郑州450002 [2]郑州人民医院,郑州450002 [3]云南中医药大学第一临床医学院,昆明650000

出　　处：《中国比较医学杂志》2024年第9期157-164,共8页Chinese Journal of Comparative Medicine

基　　金：河南省科技攻关项目(232102310403);河南省高校重点科研项目(23A360013)。

摘　　要：冠心病在中医学中属“胸痹心痛、真心痛”等范畴,脂质代谢紊乱和炎症反应可作为“痰、瘀”的生化表象,贯穿疾病始终。巨噬细胞的能量代谢与其免疫功能密切相关,是调节冠心病代谢紊乱和炎症反应的重要因素。本文综述了巨噬细胞在冠心病病理生理中的角色,讨论了这些代谢途径如何影响巨噬细胞的免疫反应,以及它们如何通过能量代谢途径影响疾病,深入探讨巨噬细胞能量代谢的不同模式,特别是促炎的M1型和抗炎的M2型巨噬细胞在冠心病痰瘀互结证中的代谢特性及其免疫调节功能。为理解冠心病痰瘀互结证的病理机制和开发新的治疗策略提供理论指导。In traditional Chinese medicine,coronary heart disease falls under the categories of“chest impediment and heart pain”and“true heart pain”,with lipid metabolism disorder and the inflammatory response acting as biochemical manifestations of“phlegm and stasis”throughout the disease.The energy metabolism of macrophages is closely related to their immune function and is an important factor in regulating the metabolic disorder and inflammatory responses in coronary heart disease.This article reviews the role of macrophages in the pathophysiology of coronary heart disease.We discuss how these metabolic pathways affect the immune responses of macrophages and influence the disease.We delve into the different modes of macrophage energy metabolism in coronary heart disease,especially the metabolic characteristics and immune regulatory functions of pro-inflammatory M1 and anti-inflammatory M2 macrophages in the syndrome of phlegm and blood stasis.This provides a theoretical guidance for understanding the pathogenic mechanism of the syndrome of phlegm and blood stasis in coronary heart disease and developing new treatment strategies.

关 键 词：巨噬细胞 能量代谢 冠心病痰瘀互结证 免疫调节 

分 类 号：R-33[医药卫生]