T细胞免疫球蛋白黏蛋白3/半乳糖凝集素9(TIM-3/galectin-9)在肿瘤免疫中的研究进展  

Research progress on T-cell immunoglobulin mucin 3/galectin 9(TIM-3/galectin-9)in tumour immunity

作　　者：马澜馨 白丽 MA Lanxin;BAI Li(School of Basic Medical Sciences,Dali University,Dali 671000,China;Yunnan Key Laboratory for Biomedical Research and Development of Insects,Dali University,Dali 671000,China)

机构地区：[1]大理大学基础医学院微生物与免疫学教研室,云南大理671000 [2]大理大学云南省昆虫生物医药研发重点实验室,云南大理671000

出　　处：《细胞与分子免疫学杂志》2024年第8期754-760,共7页Chinese Journal of Cellular and Molecular Immunology

基　　金：国家自然科学基金(81360319);云南省2019年中药饮片产业发展专项资金(2019-YG-067)。

摘　　要：随着对免疫检查点研究的不断发展,通过阻断免疫检查点对肿瘤进行靶向治疗已成为肿瘤治疗的重要手段之一。T细胞免疫球蛋白黏蛋白3(TIM-3)作为负性免疫检查点,与其配体半乳糖凝集素9(Gal-9)的结合已在多种癌症中被证明可促进肿瘤免疫逃逸。在血液、消化、呼吸系统肿瘤中,通过阻断TIM-3/Gal-9影响不同信号通路,调节机体T细胞、B细胞、树突状细胞、自然杀伤细胞、单核/巨噬细胞生长,抑制调节性T细胞发挥抗肿瘤作用。TIM-3抗体作为免疫检查点抑制剂在分子靶向抗肿瘤中具有潜在的治疗价值。文中总结了靶向TIM-3/Gal-9在多种癌症的肿瘤微环境中抗肿瘤的作用机制。With the ongoing advancement of immune checkpoint research,targeting tumors through immune checkpoint blockade has emerged as a crucial approach in cancer therapy.T cell immunoglobulin and mucin-domain containing protein 3(TIM-3)functions as a negative immune checkpoint.It has been demonstrated that the interaction of TIM-3 with its ligand galectin-9(Gal-9)can promote immune escape in a variety of cancers.In hematologic,digestive,and respiratory tumors,it affects different signaling pathways by blocking TIM-3/Gal-9 interaction,thereby regulating the growth of T cells,B cells,dendritic cells,NK cells,and monocytes/macrophages,and inhibiting regulatory T cells to exert anti-tumor effects.TIM-3 antibodies have potential therapeutic value as immune checkpoint inhibitors in molecularly-targeted anti-tumor therapy.This article reviews the mechanisms of anti-tumor effects of TIM-3/Gal-9 in the tumor microenvironment of various cancers.

关 键 词：免疫检查点 T细胞免疫球蛋白和黏蛋白3(TIM-3) 半乳糖凝集素9 肿瘤免疫 综述 

分 类 号：R73[医药卫生—肿瘤] G353.11[医药卫生—临床医学]