嵌合抗原受体巨噬细胞(CAR-M)疗法在炎症相关抑郁症治疗中的应用  

Application of chimeric antigen receptor macrophage(CAR-M)therapy in the treatment of inflammation-associated depression

作　　者：徐雨菲 王涛 XU Yufei;WANG Tao(The sixth cadet regiment,Air Force Medical University,Xi’an 710032,China;Department of Medical Genetics and Developmental Biology,Air Force Medical University,Xi’an 710032,China)

机构地区：[1]空军军医大学基础医学院学员六大队,陕西西安710032 [2]空军军医大学基础医学院医学遗传学与发育生物学教研室,陕西西安710032

出　　处：《细胞与分子免疫学杂志》2024年第9期834-838,共5页Chinese Journal of Cellular and Molecular Immunology

基　　金：国家自然科学基金面上项目(82073361)。

摘　　要：经典的嵌合抗原受体巨噬细胞(CAR-M)发挥促炎作用实现抗肿瘤免疫,但是通过改造CAR的结构设计也可以使其有类似M2的抗炎功能,从而治疗炎症性疾病。目前靶向M1型小胶质细胞的CAR-M疗法能够有效减少神经炎症,用于治疗炎症相关抑郁症。随着关于CAR-M抗炎作用的研究不断发展,CAR-M细胞疗法为治疗炎症相关疾病提供了新的思路。The classic Chimeric Antigen Receptor Macrophage(CAR-M)exerts pro-inflammatory effects to achieve anti-tumor immunity,but by modifying the structure design of CAR,it can acquire anti-inflammatory functions similar to M2,thereby treating inflammatory diseases.Currently,CAR-M therapy targeting M1-type microglial cells can effectively reduce neuroinflammation and be used to treat inflammation-related depression.With ongoing research on the anti-inflammatory effects of CAR-M,CAR-M cell therapy offers a new approach for treating inflammatory-related diseases.

关 键 词：嵌合抗原受体巨噬细胞(CAR-M) 抑郁症 炎症 治疗机制 综述 

分 类 号：R364.5[医药卫生—病理学] R457.2[医药卫生—基础医学] G353.11[文化科学—情报学]