MTSS1和RBCK1在卵巢癌组织中的表达及其与临床病理特征和预后的关系  

Expression of MTSS1 and RBCK1 in ovarian cancer tissue and their relationship with clinical pathological features and prognosis

作　　者：徐琳琳[1] 刘振娟 张子轩 李彦霞 XU Lin-lin;LIU Zhen-juan;ZHANG Zi-xuan(Department of Obstetrics and Gynecology,Qingdao Haici Hospital(Qingdao Traditional Chinese Medicine Hospital)Affiliated to Qingdao University,Qingdao Shandong 266042,China;Department of Critical Care Medicine,Qingdao Hospital of Rehabilitation University(Qingdao Municipal Hospital),Qingdao Shandong 266000,China;Rehabilitation University Qingdao Central Hospital(Qingdao Central Hospital)Health Management Center,Qingdao Shandong 266042,China)

机构地区：[1]青岛大学附属青岛市海慈医院(青岛市中医医院)妇科,山东青岛266042 [2]康复大学青岛医院(青岛市市立医院)重症医学科,山东青岛266000 [3]康复大学青岛中心医院(青岛市中心医院)健康管理中心,山东青岛266042 [4]青岛市妇女儿童医院妇科,山东青岛266000

出　　处：《临床和实验医学杂志》2024年第17期1848-1852,共5页Journal of Clinical and Experimental Medicine

基　　金：山东省医药卫生科技发展计划项目(编号:2021WS001243)。

摘　　要：目的 回顾性探讨卵巢癌组织中肿瘤转移抑制基因1(MTSS1)、ranbp2型和c3hc4型锌指1(RBCK1)表达、患者临床病理特征与预后的关系。方法 回顾性收集2021年8月至2023年8月期间青岛大学附属青岛市海慈医院(青岛市中医医院)收治的120例卵巢癌患者在术中切除的卵巢癌癌组织及其癌旁组织标本。行免疫组织化学法检测卵巢癌组织和癌旁组织中MTSS1、RBCK1的表达,并收集患者的临床资料[年龄、分化程度、淋巴结转移、国际妇产科学联合会(FIGO)分期、病理类型、腹水];采用Spearman相关性分析卵巢癌组织中MTSS1与RBCK1表达的相关性;采用Kaplan-Meier法分析卵巢癌组织MTSS1、RBCK1表达与患者预后的关系;采用Cox回归分析卵巢癌患者预后的影响因素。结果 卵巢癌组织MTSS1、RBCK1阳性表达率分别为26.67%、23.33%,低于癌旁组织MTSS1、RBCK1阳性表达率(62.50%、74.17%),差异均有统计学意义(P<0.05)。临床资料比较显示,MTSS1、RBCK1表达水平与FIGO分期、淋巴结转移及分化程度有关(P<0.05);Spearman相关分析卵巢癌组织中MTSS1和RBCK1的之间表达呈正相关(r=0.812,P<0.05)。生存分析结果显示,卵巢癌组织MTSS1、RBCK1阳性表达患者5年生存率为84.37%、82.14%,均高于MTSS1、RBCK1阴性表达患者(55.68%、57.60%),差异均有统计学意义(P<0.05)。低分化程度、FIGO分期Ⅲ+Ⅳ期、淋巴结转移、RBCK1阴性表达和MTSS1阴性表达均是卵巢癌患者死亡的危险因素(P<0.05)。结论 MTSS1、RBCK1在卵巢癌患者中低表达,且两者表达水平与淋巴结转移、FIGO分期、分化程度有关,二者可能是影响卵巢癌患者预后的特异性指标。Objective To retrospectively investigate the relationship between the expression of metastasis suppressor 1(MTSS1),RANBP2-type and C3HC4-type zinc finger-containing 1(RBCK1)in ovarian cancer tissue and the clinical pathological characteristics and prognosis of patients.Methods A total of 120 ovarian cancer patients admitted to Qingdao Haici Hospital(Qingdao Traditional Chinese Medicine Hospital)Affiliated to Qingdao University from August 2021 to August 2023 were collected for intraoperative resection of ovarian cancer tissue and its adjacent tissue samples.Immunohistochemical methods were applied to detect the expression of MTSS1 and RBCK1 in ovarian cancer tissues and adjacent cancer tissues,and clinical data[age,degree of differentiation,lymph node metastasis,International Federation of Gynecology and Obstetrics(FIGO)stage,pathological type,ascites]of patients were collected;Spearman correlation was applied to analyze the correlation between the expression of MTSS1 and RBCK1 in ovarian cancer tissues;Kaplan-Meier method was applied to analyze the relationship between the expression of MTSS1 and RBCK1 in ovarian cancer tissue and prognosis;Cox regression was applied to analyze the influencing factors of prognosis in ovarian cancer patients.Results The positive expression rates of MTSS1 and RBCK1 in adjacent tissues were 26.67%,23.33%,which were higher than ovarian cancer tissues(62.50,74.17%),the differences were statistically significant(P<0.05).Clinical data comparison showed that the expression levels of MTSS1 and RBCK1 were related to FIGO staging,lymph node metastasis,and differentiation degree(P<0.05).Spearman correlation analysis showed a positive correlation between the expression of MTSS1 and RBCK1 in ovarian cancer tissues(r=0.812,P<0.05).The survival analysis results showed that the 5-year survival rate of patients with MTSS1 and RBCK1 positive expression in ovarian cancer tissue were 84.37%and 82.14%,which were higher than higher than those of patients with negative expression of MTSS1 and RBCK1(55.

关 键 词：卵巢肿瘤 肿瘤转移抑制基因1 ranbp2型和c3hc4型锌指1 临床病理特征 预后 

分 类 号：R737.31[医药卫生—肿瘤]