中晚期喉癌患者环状软骨上喉部分切除联合辅助放疗的治疗效果及血清let-7a表达变化分析  

Prognostic evaluation and analysis of serum let-7a expression changes in patients with advanced laryngeal cancer undergoing partial cricoid cartilage resection combined with adjuvant radiotherapy

作　　者：朱翠 安玉峰 汪华 ZHU Cui;AN Yu-feng;WANG Hua(Department of Otolaryngology,Daqing Longnan Hospital,Daqing Heilongjiang 163416,China)

机构地区：[1]大庆龙南医院耳鼻喉科,黑龙江大庆163416

出　　处：《临床和实验医学杂志》2024年第17期1873-1876,共4页Journal of Clinical and Experimental Medicine

基　　金：黑龙江省自然科学基金(编号:YQ2020H034)。

摘　　要：目的 探讨中晚期喉癌患者环状软骨上喉部分切除联合辅助放疗的治疗效果及其对血清let-7a的影响。方法 前瞻性选取2018年1月至2021年12月在大庆龙南医院治疗的中晚期喉癌患者92例,采用信封法将患者分为观察组(n=46)和对照组(n=46)。观察组给予环状软骨上喉部分切除联合辅助放疗,对照组给予全喉切除术联合辅助放疗。记录两组的术后引流量、鼻饲时间、术后住院时间、喉功能恢复时间、开始试吃时间。比较两组术前、术后1周的血清let-7a表达。记录两组术前、术后3个月患者生活质量评分。术后随访观察两组预后及并发症情况。结果 观察组术后引流量、鼻饲时间和术后住院时间分别为(86.65±12.26) mL、(16.02±1.43) d和(19.87±2.68) d,均明显少于对照组[(110.45±15.51) mL、(20.05±1.41) d和(23.10±2.77) d],观察组喉功能恢复时间、开始试吃时间分别为(15.51±1.61)、(16.78±1.38) d,均明显短于对照组[(18.89±1.72)、(19.11±1.30) d],差异均有统计学意义(P<0.05)。观察组和对照组术后1周的血清let-7a相对表达量比较,差异无统计学意义(P>0.05)。观察组中位生存时间为55个月(95%CI:49.58~60.42),对照组中位生存时间为52个月(95%CI:42.24~61.76);两组中位生存时间比较,差异无统计学意义(P>0.05)。观察组的术后总并发症发生率为8.70%,明显低于对照组(26.09%),差异有统计学意义(P<0.05)。结论 环状软骨上喉部分切除联合辅助放疗与全喉切除术联合辅助放疗治疗中晚期喉癌对患者生活质量、let-7a表达水平和生存期的影响相近,但前者具有并发症少、术后恢复快的优点。Objective To explore the therapeutic effect of partial cricoid cartilage resection combined with adjuvant radiotherapy in patients with advanced laryngeal cancer and its impact on serum let-7a.Methods A total of 92 patients with advanced laryngeal cancer were admitted to Daqing Longnan Hospital from January 2018 to December 2021 for treatment.The patients were divided into the observation group(n=46)and the control group(n=46)by envelope method.The observation group received partial excision of the cricoid cartilage of the larynx combined with adjuvant radiotherapy,while the control group received total laryngectomy combined with adjuvant radiotherapy.The postoperative drainage volume,nasal feeding time,postoperative hospital stay,laryngeal function recovery time and trial eating time of the two groups were recorded.The expression of serum let-7a was compared between the two groups before and 1 week after operation.The quality of life scores of the two groups before and 3 months after operation were recorded.Postoperative follow-up was performed to observe the prognosis and complications of the two groups.Results the postoperative drainage volume,nasogastric feeding time,and postoperative hospital stay in the observation group were(86.65±12.26)mL,(16.02±1.43)d,and(19.87±2.68)d,respectively,which was significantly lower than those in the control group[(110.45±15.51)mL,(20.05±1.41)d,and(23.10±2.77)d],the recovery time of laryngeal function and the start time of tasting in the observation group were(15.51±1.61)and(16.78±1.38)days,respectively,which were significantly shorter than those in the control group[(18.89±1.72),(19.11±1.30)d],the differences were statistically significant(P<0.05).There was no statistically significant difference in the relative expression of serum let-7a between the observation and control groups at 1 week postoperatively(P>0.05).The median survival time of the observation group was 55 months(95%CI:49.58-60.42),and the median survival time of the control group was 52 months(95%CI:4

关 键 词：中晚期 喉癌 环状软骨上喉部分切除 放疗 治疗效果 let-7a 

分 类 号：R739.65[医药卫生—肿瘤]