通腑醒神汤加减联合醒脑静注射液治疗急性脑出血的临床效果  

Clinical Effect of Modified Tongfu Xingshen Decoction Combined with Xingnaojing Injection in the Treatment of Acute Cerebral Hemorrhage

作　　者：韩治光 HAN Zhiguang(Department of Emergency,Jinshui District General Hospital,Zhengzhou Henan 450003,China)

机构地区：[1]郑州市金水区总医院急诊科,河南郑州450003

出　　处：《临床研究》2024年第10期103-106,共4页Clinical Research

摘　　要：目的 探讨通腑醒神汤加减联合醒脑静注射液治疗急性脑出血的临床效果。方法 选取2022年2月至2023年2月于郑州市金水区总医院治疗的120例急性脑出血患者作为入组研究对象,使用随机数字表法将研究对象分为单药组60例、联合组60例。联合组在采用通腑醒神汤加减联合醒脑静注射液治疗,单药组使用醒脑静注射液治疗,对比单药组和联合组临床疗效、血管内皮功能指标、炎性细胞因子、血液流变学、神经功能缺损及不良反应发生率。结果 治疗后,联合组治疗有效率高于单药组,差异有统计学意义(P <0.05);联合组不良反应发生率与单药组比较,差异无统计学意义(P> 0.05)。治疗前,两组血液流变学指标、血管内皮功能、神经功能缺损评分及炎性细胞因子水平比较差异无统计学意义(P> 0.05);治疗后,两组低切还原黏度、高切还原黏度、内皮素-1(ET-1)、神经功能缺损程度及炎性细胞因子水平均低于治疗前,一氧化氮(NO)水平高于治疗前,且联合组低切还原黏度、高切还原黏度、ET-1、神经功能缺损程度及炎性细胞因子水平均低于单药组,NO水平高于单药组,差异具有统计学意义(P <0.05)。结论 通腑醒神汤加减联合醒脑静注射液治疗可提高临床治疗效果,改善血液流变学指标及血管内皮功能;减少神经功能缺损程度,并降低炎性细胞因子水平,促进急性脑出血患者身体恢复。Objective To investigate the clinical effect of Modified Tongfu Xingshen Decoction combined with Xingnaojing Injection in the treatment of acute cerebral hemorrhage.Methods A total of 120 patients with acute cerebral hemorrhage treated at Jinshui District General Hospital from February 2022 to February 2023 were selected as study subjects.The subjects were divided into a single-drug group(60 cases)and a combined group(60 cases)using the random number table method.The combined group was treated with modified Tongfu Xingshen Decoction combined with Xingnaojing Injection,while the single-drug group was treated with Xingnaojing Injection alone.The clinical efficacy,vascular endothelial function indicators,inflammatory cytokines,hemorheology,neurological deficit,and incidence of adverse reactions were compared between the single-drug group and the combination group.Results After treatment,the effective rate of the combined group was higher than that of the single-drug group,with a statistically significant difference(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the combined group and the single-drug group(P>0.05).Before treatment,there were no statistically significant differences in hemorheology indicators,vascular endothelial function,neurological deficit scores,and inflammatory cytokine levels between the two groups(P>0.05).After treatment,the low-shear reduced viscosity,high-shear reduced viscosity,endothelin-1(ET-1),neurological deficit degree,and inflammatory cytokine levels of both groups were lower than before treatment,while the nitric oxide(NO)level was higher than before treatment.In addition,The low-shear reduced viscosity,high-shear reduced viscosity,ET-1,neurological deficit degree,and inflammatory cytokine levels of the combined group were lower than those of the single-drug group,while the NO level was higher than that of the single-drug group,with statistically significant differences(P<0.05).Conclusion Modified Tongfu Xingshen Decoction combi

关 键 词：通腑醒神汤加减 急性脑出血 醒脑静注射液 炎性细胞因子 神经功能缺损 

分 类 号：R743.3[医药卫生—神经病学与精神病学]