CA125、HE4、AMH对子宫肌瘤的鉴别诊断价值  

Differential Diagnostic Value of CA125,HE4,and AMH in Uterine Fibroids

作　　者：汪显运 郭锋 WANG Xianyun;GUO Feng(Department of Medical Laboratory,Sanmenxia Central Hospital,Sanmenxia Henan 472000,China)

机构地区：[1]三门峡市中心医院医学检验科,河南三门峡472000

出　　处：《临床研究》2024年第10期139-142,共4页Clinical Research

摘　　要：目的 探讨糖类抗原-125(CA125)、人附睾蛋白4(HE4)、抗苗勒管激素(AMH)对子宫肌瘤的鉴别诊断价值。方法 选取三门峡市中心医院2022年1月至2023年1月收治的55例子宫肌瘤患者作为子宫肌瘤组,同期55例子宫腺肌病患者作为子宫腺肌病组,另选取60例健康体检者作为对照组。比较三组研究对象CA125、HE4、AMH水平,分析CA125、HE4、AMH与临床相关指标的关系,分析CA125、HE4、AMH诊断子宫肌瘤的灵敏度和特异度并绘制受试者工作曲线(ROC曲线)。结果 子宫腺肌病组血清CA125、HE4、AMH水平高于子宫肌瘤组和对照组,子宫肌瘤组高于对照组,差异有统计学意义(F=54.937、61.958、38.539,P <0.05);子宫肌瘤患者血清CA125、HE4、AMH与流产次数、妊娠胎次、妇科疾病、乳腺增生有关,差异有统计学意义(P <0.05);血清CA125、HE4、AMH联合检测诊断子宫肌瘤的曲线下面积(AUC值)高于单项检测,差异有统计学意义(P <0.05)。结论 血清CA125、HE4、AMH联合检测对子宫肌瘤的鉴别诊断价值较高,可提升诊断准确率。Objective To explore the differential diagnostic value of carbohydrate antigen-125(CA125),human epididymis protein 4(HE4),and anti-Müllerian hormone(AMH)in uterine fibroids.Methods 55 patients with uterine fibroids treated at Sanmenxia Central Hospital from January 2022 to January 2023 were selected as the uterine fibroid group.55 patients with adenomyosis during the same period were selected as the adenomyosis group,and 60 healthy individuals were selected as the control group.The levels of CA125,HE4,and AMH were compared among the three groups.The relationship between CA125,HE4,and AMH and clinical indicators was analyzed.The sensitivity and specificity of CA125,HE4,and AMH in diagnosing uterine fibroids were analyzed,and receiver operating characteristic(ROC)curves were plotted.Results The serum levels of CA125,HE4,and AMH in the adenomyosis group were higher than those in the uterine fibroid group and the control group,and the levels in the uterine fibroid group were higher than those in the control group,with statistically significant differences(F=54.937,61.958,38.539,P<0.05).The serum levels of CA125,HE4,and AMH in patients with uterine fibroids were related to the number of miscarriages,number of pregnancies,gynecological diseases,and breast hyperplasia,with statistically significant differences(P<0.05).The area under the curve(AUC)for the combined detection of serum CA125,HE4,and AMH in diagnosing uterine fibroids was higher than that for single-item detection,with statistically significant differences(P<0.05).Conclusion The combined detection of serum CA125,HE4,and AMH has a high differential diagnostic value for uterine fibroids and can improve diagnostic accuracy.

关 键 词：子宫肌瘤 糖类抗原-125 人附睾蛋白4 抗苗勒管激素 鉴别诊断 

分 类 号：R730.41[医药卫生—肿瘤]