PI3K/Akt/mTOR、Wnt/-catenin、JAK/STAT信号通路及黄酮类物质对胃癌的影响  

The effects of PI3K/Akt/mTOR,Wnt/-catenin,JAK/STAT signaling pathways and flavonoids on gastric cancer

作　　者：张佳奇 高慧娟 张乐乐 李双芳 刘生杰 ZHANG Jiaqi;GAO Huijuan;Zhang Lele;Li Shuangfang;LIU Shengjie(School of Biology and Food Engineering,Fuyang Normal University,Fuyang,Anhui 236037,China;College of Information Engineering,Fuyang Normal University,Fuyang,Anhui 236037,China)

机构地区：[1]阜阳师范大学生物与食品工程学院,安徽阜阳236037 [2]阜阳师范大学信息工程学院,安徽阜阳236037

出　　处：《阜阳师范大学学报（自然科学版）》2024年第2期44-49,共6页Journal of Fuyang Normal University:Natural Science

基　　金：阜阳地方农产品食品工艺开发科研创新团队项目(FX2020KCT02)。

摘　　要：胃癌是胃黏膜上皮源性的恶性肿瘤疾病,往往伴随细胞增殖或代谢信号通路异常而发生。黄酮类化合物是多种植物的次级代谢物,属于2-苯基色原酮为母核的多样化芳香类分子家族,具有对机体细胞多靶点抗炎、抗氧化、抗肿瘤及免疫调节等生物学活性,多项研究表明其对多种常见癌症如结肠癌、乳腺癌、肺癌和胃癌等有较为显著的治愈效果。本文综述了近年来有关胃癌靶点的三条信号通路PI3K/Akt/mTOR、Wnt/β-catenin和JAK/STAT的作用机制及黄酮类化合物对胃癌信号通路影响的研究成果,为探索黄酮类物质对胃癌的防治研究提供参考。Gastric cancer is a malignant tumor of epithelial origin of gastric mucosa,which often occurs with abnormal cell proliferation or metabolic signal pathway.Flavonoids are secondary metabolites of many plants.They belong to a diverse family of aromatic molecules with 2-phenylchromogen as the maternal core.They have anti-inflammatory,anti-oxidation,anti-tumor,immune regulation and other biological activities to multi-targets of the body's cells.Many studies have shown that it has significant curative effect on many common cancers,such as colon cancer,breast cancer,lung cancer,stomach cancer,etc.This article reviews the recent studies on the three target signaling pathways of gastric cancer:PI3K/Akt/mTOR,Wnt/β-catenin and JAK/STAT.The mechanism of these signal pathways and the effect of flavonoids on them are reviewed to provide reference for exploring the prevention and treatment of gastric cancer by flavonoids.

关 键 词：胃癌 信号通路 作用机制 黄酮 

分 类 号：R735.2[医药卫生—肿瘤] Q257[医药卫生—临床医学]