疣状角化不良瘤6例临床及组织病理分析  

Warty dyskeratoma:clinicopathologic analysis of six cases

作　　者：杨庆华[1] 李铖铖 曾婉婷 景海霞[1] YANG Qinghua;LI Chengcheng;ZENG Wanting;JING Haixia(Department of Dermatology,Taihe Hospital,Affiliated Hospital of Hubei University of Medicine,Shiyan 442000,China;Department of Critical Medicine,Taihe Hospital,Affliated Hospital of Hubei University of Medicine,Shiyan 442000,China)

机构地区：[1]十堰市太和医院皮肤科,湖北十堰442000 [2]十堰市太和医院重症医学科,湖北十堰442000

出　　处：《临床皮肤科杂志》2024年第10期592-595,共4页Journal of Clinical Dermatology

摘　　要：目的:分析疣状角化不良瘤的临床及组织病理学特征。方法:回顾性分析6例疣状角化不良瘤患者的临床及组织病理资料。结果:6例疣状角化不良瘤患者男女比率为2∶1,平均年龄(49.8±12.1)岁,皮损均表现为头部的单发丘疹(1例)或结节(5例)。组织病理学上,本组患者皮损主要表现为2种结构模式,即杯状型(3例)和囊状型(3例)。本病典型组织病理特征为上皮成分均显示有灶状的棘层松解性角化不良;也可观察到提示向毛囊漏斗部分化的多种特征,包括局部与毛囊皮脂腺单位相邻(4例),以及存在小的漏斗部囊性结构(1例)。结论:疣状角化不良瘤皮损形态表现多样,大部分皮损组织病理特征整体上符合毛囊附属器肿瘤。Objective:To analyze the clinical and histopathologic characteristics of warty dyskeratoma(WD).Methods:The clini cal and histopathological data of six patients with WD were retrospectively analyzed.Results:A total of six cases with WD(M/F ratio 2:1,mean age 49.8+12.1 years)presented with solitary papule in one case or nodule in five cases on the head.Histopatholo-gically,lesions showed mainly two architectural patterns,namely,cup-shaped(3 cases)and cystic(3 cases).Characteristically,the epithelial component in all patients displayed foci of acantholytic dyskeratosis.Variable features suggestive of follicular differ-entiation toward the infundibular portion of a normal hair follicle were also observed,including a focal contiguity to piloseba-ceous units in most cases(4 cases),and the presence of small infundibular cystic structures in 1 case.Conclusion:WD shows a wide spectrum of morphologic features.The majority of these lesions display overall histopathologic features consistent with a follicular adnexal neoplasm.

关 键 词：疣状角化不良瘤 组织病理 

分 类 号：R739.5[医药卫生—肿瘤]