氯吡格雷联合依达拉奉右莰醇注射用浓溶液治疗对进展性脑卒中血清Hcy、FIB及CRP水平的影响  

Effect of clopidogrel combined with Edaravone dextrocamphorol injection on serum Hcy,FIB and CRP levels in patients with progressive stroke

作　　者：牛峰志 李家辉 姚昕彤 龚燕丽 常群 NIU Fengzhi;LI Jiahui;YAO Xintong;GONG Yanli;CHANG Qun(Department of Pharmacy,Linquan County People's Hospital,Fuyang,Anhui,China,236400;Department of Neurology,Fuyang People's Hospital,Fuyang,Anhui,China,236400;Department of Neurology,Linquan County People's Hospital,Fuyang,Anhui,China,236400)

机构地区：[1]临泉县人民医院药剂科,安徽阜阳236400 [2]阜阳市人民医院神经内科,安徽阜阳236000 [3]临泉县人民医院神经内科,安徽阜阳236400

出　　处：《分子诊断与治疗杂志》2024年第9期1755-1758,共4页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省自然科学研究项目(KJ2022A0238)。

摘　　要：目的探究氯吡格雷联合依达拉奉右莰醇注射用浓溶液治疗对进展性脑卒中血清同型半胱氨酸(Hcy)、纤维蛋白原(FIB)及C反应蛋白(CRP)水平的影响。方法选取2021年1月至2024年1月临泉县人民医院收治的122例进展性脑卒中患者,根据治疗方法的差异将其分为对照组(予以氯吡格雷治疗,n=60例)与试验组(予以氯吡格雷联合依达拉奉右莰醇注射用浓溶液治疗,n=62例)。对比两组临床疗效、Hcy、CRP水平、凝血功能[纤维蛋白原浓度(FIB)、活化部分凝血活酶时间(APTT)及凝血酶原时间(PT)]及不良反应发生情况。结果试验组临床总有效率(95.16%)比对照组临床总有效率(75.00%)高,差异有统计学意义(P<0.05)。治疗7 d后,两组Hcy、CRP水平均降低,且试验组Hcy、CRP水平比对照组低,差异有统计学意义(P<0.05)。治疗7 d后,两组FIB水平下降,APTT、PT水平上升,且试验组FIB水平比对照组低,APTT、PT水平比对照组,差异有统计学意义(P<0.05)。对照组、试验组不良反应总发生率分别为10.00%、11.29%,两组比较差异无统计学意义(P>0.05)。结论氯吡格雷联合依达拉奉右莰醇注射用浓溶液治疗可有效提高进展性脑卒中患者临床疗效,改善血清Hcy、FIB、CRP水平,具有较高安全性。Objective To explore the effects of clopidogrel combined with Edaravone dextrocam-phorol injection on serum homocysteine(Hcy),fibrinogen(FIB)and C-reactive protein(CRP)levels in pa-tients with progressive stroke.Methods A total of 122 patients with progressive stroke admitted to the People's Hospital of Linquan County from January 2021 to January 2024 were selected and divided into the control group(treated with clopidogrel,n=60 cases)and the experimental group(treated with clopidogrel combined with Edaravone dexpramphenol injection and concentrated solution,n=62 cases)according to the differences in treatment methods.To compare the clinical efficacy,Hcy,CRP levels,coagulation function[fibrinogen concentration(FIB),activated partial thromboplastin time(APTT)and prothrombin time(PT)]and the oc-currence of adverse reactions were observed.Results The total clinical effective rate of the experimental group(95.16%)was higher than that of the control group(75.00%),and the difference was statistically sig-nificant(75.00%)(P<0.05).After 7 days of treatment,Hcy and CRP levels decreased in both groups,and Hcy and CRP levels were lower in the experimental group than in the control group,and the difference was sta-tistically significant(P<0.05)After 7 days of treatment,FIB levels decreased and APTT and PT levels in-creased in both groups,and FIB levels were lower and APTT and PT levels were higher in the experimental group than in the control group,and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the control group and the experimental group was 10.00%and 11.29%,The difference between the two groups was not statistically significant(P<0.05).Conclusion Clopidogrel combined with Edaravone and dexamfetamine injection in a concentrated solution,can effectively enhance the clinical efficacy of patients with progressive stroke.This treatment also helps improve serum Hcy,FIB,CRP levels,while maintaining a high level of safety.

关 键 词：氯吡格雷 依达拉奉右莰醇注射用浓溶液 进展性脑卒中 Hcy FIB CRP 

分 类 号：R743.3[医药卫生—神经病学与精神病学]