The circadian clock in enamel development  

作　　者：Ke Wu Xiaochan Li Yunyang Bai Boon Chin Heng Xuehui Zhang Xuliang Deng 

机构地区：[1]Department of Geriatric Dentistry,Peking University School and Hospital of Stomatology,Beijing,China [2]4th Division,Peking University School and Hospital of Stomatology,Beijing,China [3]Department of Dental Materials&Dental Medical Devices Testing Center,Peking University School and Hospital of Stomatology,Beijing,China [4]National Engineering Research Center of Oral Biomaterials and Digital Medical Devices,NMPA Key Laboratory for Dental Materials,Beijing Laboratory of Biomedical Materials&Beijing Key Laboratory of Digital Stomatology,Peking University School and Hospital of Stomatology,Beijing,China [5]Oral Translational Medicine Research Center Joint Training base for Shanxi Provincial Key Laboratory in Oral and Maxillofacial Repair Reconstruction and Regeneration The First People’s Hospital of Jinzhong,Jinzhong,China

出　　处：《International Journal of Oral Science》2024年第3期371-380,共10页国际口腔科学杂志（英文版）

基　　金：supported by grants from the National Key R&D Program of China(2022YFC2401803);the National Natural Science Foundation of China(51973004);the China Postdoctoral Science Foundation(2023M730116);the Peking University Medicine Sailing Program for YoungScholars’Scientific&Technological Innovation(BMU2023YFJHPY012).

摘　　要：Circadian rhythms are self-sustaining oscillations within biological systems that play key roles in a diverse multitude of physiological processes.The circadian clock mechanisms in brain and peripheral tissues can oscillate independently or be synchronized/disrupted by external stimuli.Dental enamel is a type of mineralized tissue that forms the exterior surface of the tooth crown.Incremental Retzius lines are readily observable microstructures of mature tooth enamel that indicate the regulation of amelogenesis by circadian rhythms.Teeth enamel is formed by enamel-forming cells known as ameloblasts,which are regulated and orchestrated by the circadian clock during amelogenesis.This review will first examine the key roles of the circadian clock in regulating ameloblasts and amelogenesis.Several physiological processes are involved,including gene expression,cell morphology,metabolic changes,matrix deposition,ion transportation,and mineralization.Next,the potential detrimental effects of circadian rhythm disruption on enamel formation are discussed.Circadian rhythm disruption can directly lead to Enamel Hypoplasia,which might also be a potential causative mechanism of amelogenesis imperfecta.Finally,future research trajectory in this field is extrapolated.It is hoped that this review will inspire more intensive research efforts and provide relevant cues in formulating novel therapeutic strategies for preventing tooth enamel developmental abnormalities.

关 键 词：ENAMEL CROWN EXTERIOR 

分 类 号：R781[医药卫生—口腔医学]