Tetrahedral framework nucleic acids/hyaluronic acidmethacrylic anhydride hybrid hydrogel with antimicrobial and anti-inflammatory properties for infected wound healing  

作　　者：Cai Qi Qiang Sun Dexuan Xiao Mei Zhang Shaojingya Gao Bin Guo Yunfeng Lin 

机构地区：[1]State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology,Sichuan University,Chengdu,China [2]Sichuan Provincial Engineering Research Center of Oral Biomaterials,Chengdu,China [3]Department of Stomatology,The First Medical Centre,Chinese PLA General Hospital,Beijing,China

出　　处：《International Journal of Oral Science》2024年第3期436-447,共12页国际口腔科学杂志（英文版）

基　　金：supported by National Key R&D Program of China(2019YFA0110600);National Natural Science Foundation of China(82370929,81970916);Sichuan Science and Technology Program(2022NSFSC0002);Sichuan Province Youth Science and Technology Innovation Team(2022JDTD0021);Research and Develop Program,West China Hospital of Stomatology Sichuan University(RD03202302)。

摘　　要：Bacterial resistance and excessive inflammation are common issues that hinder wound healing.Antimicrobial peptides(AMPs)offer a promising and versatile antibacterial option compared to traditional antibiotics,with additional anti-inflammatory properties.However,the applications of AMPs are limited by their antimicrobial effects and stability against bacterial degradation.TFNAs are regarded as a promising drug delivery platform that could enhance the antibacterial properties and stability of nanodrugs.Therefore,in this study,a composite hydrogel(HAMA/t-GL13K)was prepared via the photocross-linking method,in which tFNAs carry GL13K.The hydrogel was injectable,biocompatible,and could be instantly photocured.It exhibited broad-spectrum antibacterial and anti-inflammatory properties by inhibiting the expression of inflammatory factors and scavenging ROS.Thereby,the hydrogel inhibited bacterial infection,shortened the wound healing time of skin defects in infected skin full-thickness defect wound models and reduced scarring.The constructed HAMA/tFNA-AMPs hydrogels exhibit the potential for clinical use in treating microbial infections and promoting wound healing.

关 键 词：properties. HYDROGEL ANHYDRIDE 

分 类 号：R783.1[医药卫生—口腔医学]