原发卵巢Müllerian腺肉瘤1例及文献回顾  

A case report of primary Müllerian adenosarcoma of the ovary and literature review

作　　者：蒲萄 钟芳芳 张晓燕[3] 时冬冬 徐丛剑 蒋红元 范灵玲 PU Tao;ZHONG Fang-fang;ZHANG Xiao-yan;SHI Dong-dong;XU Cong-jian;JIANG Hong-yuan;FAN Ling-ling(Department of Gynecology,Fudan University,Shanghai 200011,China;Department of Pathology,Obstetrics and Gynecology Hospital,Fudan University,Shanghai 200011,China;Department of Drug Clinical Trial Institution,Obstetrics and Gynecology Hospital,Fudan University,Shanghai 200011,China)

机构地区：[1]复旦大学附属妇产科医院妇科,上海200011 [2]复旦大学附属妇产科医院病理科,上海200011 [3]复旦大学附属妇产科医院药物临床试验机构,上海200011

出　　处：《复旦学报（医学版）》2024年第5期850-856,共7页Fudan University Journal of Medical Sciences

基　　金：国家自然科学基金(82172747)。

摘　　要：报道复旦大学附属妇产科医院于2022年收治的原发性卵巢Müllerian腺肉瘤(Müllerian adenosarcoma,MA)1例,并进行文献复习,分享卵巢腺肉瘤的诊治经验。患者,女性,29岁,未婚育,外院行腹腔镜下卵巢病损切除术,术中探查见“右侧卵巢体积增大,下极可见大小约11 cm×8 cm的菜花样肿块,无包膜,质地似鱼肉样,完全切除肿块送检”。术后经北京某(三甲)医院及我院病理科会诊提示卵巢腺肉瘤,遂行全面分期手术:腹腔镜下右侧输卵管卵巢切除术、左侧卵巢囊肿剥除术、大网膜切除术、腹膜多点活检术;宫腔镜下宫颈管占位切除术。术后予紫杉醇+异环磷酰胺化疗4周期。患者化疗结束后定期随访,目前术后近2年随访期间无复发征象。This article reports a case of primary Müllerian adenosarcoma(MA)of the ovary admitted to the Obstetrics and Gynecology Hospital,Fudan University in 2022,reviews the literature on this rare disease,and shares the experience of its diagnosis and treatment.The patient was a 29-year-old unmarried woman who underwent laparoscopic resection of an ovarian lesion in another hospital.Intraoperatively,it was observed that“the right ovary was enlarged with a cauliflower-shaped mass at the lower pole,measuring about 11 cm×8 cm,unencapsulated,with a fish-like texture,which was completely excised and sent for examination.”Postoperative consultation with a(tertiary)hospital in Beijing and our pathology department suggested the diagnosis of ovarian adenosarcoma.Therefore,we performed a comprehensive staged surgery for the patient,i.e.,laparoscopic right salpingo-oophorectomy,cystectomy of the left ovary,omentectomy,multiple peritoneal biopsies,and hysteroscopic resection of cervical canal lesions.The patient received four cycles of postoperative chemotherapy with paclitaxel and ifosfamide.After chemotherapy,the patient has been regular followed up and showed no signs of recurrence during the almost 2-year postoperative follow-up period.

关 键 词：Müllerian腺肉瘤(MA) 卵巢腺肉瘤 罕见肿瘤 肿瘤辅助治疗 

分 类 号：R711[医药卫生—妇产科学] R737.31[医药卫生—临床医学]