联合免疫治疗后恶性肿瘤放疗远隔效应的研究进展  

Research progress on abscopal effect of radiotherapy combined with immunotherapy for malignant tumors

作　　者：周盛颖 丁行晨 王勇 胡漫 Shengying;Ding Xingchen;Wang Yong;Hu Man(School of Clinical Medicine,Shandong Second Medical University,Weifang 261053,China;Department of Radiation Oncology,Shandong Cancer Hospital and Institute,Shandong First Medical University and Shandong Academy of Medical Sciences,Jinan 250117,China;Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army,Jinan 250031,China)

机构地区：[1]山东第二医科大学临床医学院,潍坊261053 [2]山东省肿瘤防治研究院(山东省肿瘤医院)放疗科,山东第一医科大学(山东省医学科学院),济南250117 [3]中国人民解放军联勤保障部队第960医院,济南250031

出　　处：《中华放射肿瘤学杂志》2024年第10期964-970,共7页Chinese Journal of Radiation Oncology

基　　金：国家自然科学基金面上项目(82272751);山东省自然科学基金联合项目(ZR2021 LSW002);济南市科技计划(202225013);中国博士后科学基金项目(2023 M734299)。

摘　　要：远隔效应(AE)是指在肿瘤接受放疗时,除了直接照射的病灶被杀伤外,其他未照射的病灶也出现了缩小现象。随着程序性死亡受体1(PD-1)、程序性死亡配体1(PD-L1)、细胞毒性T淋巴细胞相关蛋白4(CTL-4)抗体的广泛应用,恶性肿瘤的治疗进入到免疫治疗时代。随着放疗与免疫治疗的联合应用越来越多,AE得到学者们前所未有的关注。放疗与免疫治疗的结合可以促进全身免疫反应的发生,进而增强放疗的抗肿瘤反应,使得人们对AE的认识更加深入。本文回顾了AE在放疗不同时期的发展历史,并着重强调了影响AE发生的各种因素及可能机制和临床研究现状,旨在探索在免疫治疗时代提高AE发生率的方法,进而促进放疗联合免疫疗法在临床应用中的客观有效性,进一步改善肿瘤患者预后。Abscopal effect(AE)is defined as the phenomenon that the non-irradiated lesions shrink in addition to the directly irradiated lesions when the tumors are treated with radiotherapy.With widespread application of programmed cell death receptor-1(PD-1),programmed cell death ligand-1(PD-L1),cytotoxic T-lymphocyte-associated protein 4(CTL-4)antibody,the treatment of malignant tumors has entered the era of immunotherapy.With the increasing application of radiotherapy combined with immunotherapy,AE has received unprecedented attention from scholars.The combination of radiotherapy and immunotherapy can promote the occurrence of systemic immune response and enhance the anti-tumor response of radiotherapy,which has deepened the understanding of AE.In this article,the history of AE in different stages of radiotherapy was reviewed,and the factors,possible mechanisms and clinical research status affecting the incidence of AE were emphasized,aiming to increase the incidence of AE in the era of immunotherapy,promote the objective effectiveness of radiotherapy combined with immunotherapy in clinical application,and further improve clinical prognosis of patients with malignant tumors.

关 键 词：放射疗法 远隔效应 放射疗法联合免疫疗法 肿瘤微环境 

分 类 号：R730.51[医药卫生—肿瘤]