血清超敏CRP对抑郁症患者SNRI类药物治疗效果的影响研究  

Effect of Serum Hypersensitive CRP on the Therapeutic Effect of SNRI Drugs in Patients with Depression

作　　者：沙蕾[1] 翁何霞[2] SHA Lei;WENG Hexia(Department of Clinical Laboratory,the First Affiliated Hospital of Nanyang Medical College,Nanyang 473000,Henan,China;Department of Pharmacy,Department of Medicine,Nanyang Medical College,Nanyang 473000,Henan,China)

机构地区：[1]南阳医学高等专科学校第一附属医院检验科,河南南阳473000 [2]南阳医学高等专科学校药学系药学教研室,河南南阳473000

出　　处：《中国药物滥用防治杂志》2024年第9期1595-1599,共5页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：河南省科技厅科技攻关基金项目(编号:152102310025)。

摘　　要：目的:探究血清超敏C反应蛋白(CRP)对抑郁症患者NE/5-HT再摄取抑制剂(SNRI)类药物治疗效果的影响。方法:回顾性分析我院2022年1月—2023年1月64例抑郁症患者的临床资料,检测血清超敏CRP水平,与同期40例健康者的血清超敏CRP水平进行比较,分析超敏CRP在抑郁症患者中的诊断价值。所有患者均应用SNRI类药物治疗,依据治疗前血清超敏CRP水平将抑郁症患者分为低CRP组(<5mg/L)、高CRP组(≥5mg/L),比较两组患者的临床资料、治疗效果,使用KaplanMeier生存分析与Cox比例风险回归模型分析血清超敏CRP水平对SNRI类药物治疗中的作用。结果:抑郁症组患者治疗前血清超敏CRP水平高于健康组(P<0.05);抑郁症组患者治疗后血清超敏CRP水平与健康组比较无差异(P>0.05)。抑郁症患者高CRP组与低CRP组性别、年龄、BMI指数、病程、病情程度比较,差异有统计学意义(P<0.05)。抑郁症高CRP组用药时间高于低CRP组,治疗有效率低于低CRP组,差异有统计学意义(P<0.05)。使用KaplanMeier生存分析,在SNRI类药物治疗中,高CRP组与低CRP组患者的治疗有效率有明显差异(χ^(2)=4.837,P=0.038,df=1)。经Cox比例风险回归模型分析,控制混杂因素后,低CRP组患者SNRI类药物的治疗有效率高于高CRP组(P<0.043,HR=1.291,95%CI:1.001~1.623),且病程是治疗效果的独立预测因素。结论:抑郁症患者的血清超敏CRP水平升高,而高超敏CRP水平会影响SNRI药物的治疗效果。Objective:To explore the effect of serum high-sensitivity C-reactive protein(CRP)on the therapeutic effect of NE/5-HT reuptake inhibitors(SNRI)in patients with depression.Methods:The clinical data of 64 patients with depression in our hospital from January 2022 to January 2023 were retrospectively analyzed.The serum high-sensitivity CRP level was detected and compared with the serum high-sensitivity CRP level of 40 healthy people in the same period.The diagnostic value of high-sensitivity CRP in patients with depression was analyzed.All patients were treated with SNRI drugs.According to the level of serum high-sensitivity CRP before treatment,patients with depression were divided into low CRP group(<5 mg/L)and high CRP group(≥5 mg/L).The clinical data and therapeutic effects of the two groups were compared.Kaplan-Meier survival analysis and Cox proportional hazard regression model were used to analyze the effect of serum high-sensitivity CRP level on SNRI drug treatment.Results:The level of serum high-sensitivity CRP in the depression group was higher than that in the healthy group before treatment(P<0.05).There was no difference in serum hypersensitive CRP level between the depression group and the healthy group after treatment(P>0.05).There were significant differences in gender,age,BMI index,course of disease and degree of illness between the high CRP group and the low CRP group in patients with depression(P<0.05).The medication time of the depression high CRP group was higher than that of the low CRP group,and the effective rate of treatment was lower than that of the low CRP group,the differences were statistically significant(P<0.05).Kaplan-Meier survival analysis showed that there was a significant difference in the effective rate between the high CRP group and the low CRP group in the treatment of SNRI drugs(χ^(2)=4.837,P=0.038,df=1).Cox proportional hazard regression model analysis showed that after controlling for confounding factors,the effective rate of SNRI drugs in the low CRP group was higher th

关 键 词：超敏C反应蛋白 抑郁症 NE/5-HT再摄取抑制剂 疗效 

分 类 号：R749.4[医药卫生—神经病学与精神病学]