基于周期性加热模式的激光消融组织效果快速预测及优化设计方法  

Rapid Prediction and Optimization Design Method of Laser⁃Ablation Effect Based on Periodic Heating Mode

作　　者：肖玉 张泽龙 简梦华 董威[1] Xiao Yu;Zhang Zelong;Jian Menghua;Dong Wei(School of Mechanical Engineering,Shanghai Jiao Tong University,Shanghai,200240,China)

机构地区：[1]上海交通大学机械与动力工程学院,上海200240

出　　处：《中国激光》2024年第15期152-161,共10页Chinese Journal of Lasers

基　　金：上海交通大学科技创新专项(YG2023LC10)。

摘　　要：激光消融技术以其高精度、强可控性和微创性等优势,在癌症治疗领域中展现出广阔的应用前景。为确保在肿瘤组织被完全消融的同时,激光消融技术对正常组织的热损伤最小,提出了一种基于周期性加热模式的辐照参数优化设计方法。首先,建立激光消融过程中生物传热和热损伤的数值模拟模型,通过实验验证该模型的准确性。随后,利用径向基函数神经网络建立激光消融效果预测模型,以快速、精准地评估正常组织的不可逆热损伤体积、不可逆热损伤总体积,以及肿瘤组织表面的平均温度。最后,采用遗传算法开展激光消融技术的单目标优化设计,在肿瘤组织完全消融和肿瘤组织表面的平均温度不超过70℃的前提下,正常组织的不可逆热损伤体积仅占不可逆热损伤总体积的0.053%,实现了激光消融技术对正常组织的不可逆热损伤的最小化目标。Objective Laser ablation,owing to its advantages of high precision,strong controllability,and minimal invasiveness,is utilized widely for cancer treatment.However,this technology is affected by the elevated surface temperatures of biological tissues and the potential of irreversible thermal damage to adjacent normal tissues in clinical applications.To mitigate surface overheating in biological tissues,researchers have proposed employing forced convection cooling,implementing periodic heating patterns,and integrating laser-energy-modulation techniques to regulate laser-energy delivery.To address irreversible thermal damage to normal tissues,a prevalent strategy is the intratumoral injection of gold nanoparticles to significantly enhance laser-light absorption.Researchers have investigated various types of gold nanoparticles as near-infrared laser absorbers as well as the effects of parameters,such as laser settings,irradiation duration,and gold-nanoparticle volume fraction,on the efficacy of laser ablation.Nevertheless,previous studies have rarely focused on the optimization of laser-irradiation parameters using optimization algorithms without relying on external agents such as gold nanoparticles or other photosensitizers to ensure the complete eradication of tumor tissues while minimizing irreversible thermal harm to normal tissues.Methods In this study,we devise a method to rapidly predict and optimize laser-ablation effects via a cyclic heating mode.Initially,we simulate the heat distribution from laser photons in biological tissues using the Monte Carlo method.Subsequently,we employ the Pennes biological heat-transfer model and the Arrhenius model in simulations to obtain the temperature distribution and thermal-damage profiles of the biological tissues.To validate the accuracy of our established numerical simulation method for solving biological heat transfer and thermal damage,we construct an experimental platform for the laser irradiation of isolated porcine liver tissue(Fig.7).Subsequently,we conduct Latin

关 键 词：激光消融 辐照参数 热损伤 神经网络 遗传算法 

分 类 号：R318.51[医药卫生—生物医学工程]