锌转运蛋白家族在胰腺癌中的作用  

Role of zinc transporter family in pancreatic cancer

作　　者：汪洋[1,2] 欧阳倩 吕浩[3,4] 唐景峰 WANG Yang;OUYANG Qian;LYU Hao;TANG Jingfeng(“111”Intelligence Introduction Base of Cell Regulation and Molecular Medicine,Ministry of Science and Technology/Ministry of Education,Hubei University of Technology,Wuhan 430068,China;Key Laboratory of Fermentation Engineering,Ministry of Education,Hubei University of Technology,Wuhan 430068,China;Collaborative Innovation Center for Industrial Fermentation,Hubei University of Technology,Wuhan 430068,China;Hubei Provincial Key Laboratory of Industrial Microbiology,Hubei University of Technology,Wuhan 430068,China)

机构地区：[1]湖北工业大学科技部/教育部细胞调控与分子药物学科“111”引智基地,湖北武汉430068 [2]湖北工业大学发酵工程教育部重点实验室,湖北武汉430068 [3]湖北工业大学工业发酵省部共建协同创新中心,湖北武汉430068 [4]湖北工业大学工业微生物湖北省重点实验室,湖北武汉430068

出　　处：《基础医学与临床》2024年第10期1455-1459,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金(82273970,82304561)。

摘　　要：Zn^(2+)作为生物体内必须的微量元素,参与蛋白质结构形成,作为辅酶因子影响细胞稳态,Zn^(2+)稳态失衡与胰腺癌的发生转移密切相关。细胞Zn^(2+)稳态由ZIP、ZnT两个锌转运蛋白质家族调控,介导细胞增殖、分化和死亡的过程。ZIP蛋白质家族主要通过RAS/RREB1、cAMP/JAK/STAT信号通路等参与DNA损伤修复、细胞免疫、外泌体分泌和上皮细胞-间充质转化(EMT)过程,从而影响胰腺癌。而ZnT蛋白质家族主要通过ERK、p38MAPK、NF-κB、mTOR通路等促进胰腺癌的发生发展。为胰腺癌的预防、诊断、治疗、预后提供一定的理论依据。As an essential trace element in organisms,Zn^(2+)is involved in the formation of protein structure and as a coenzyme factor affects cell homeostasis.The imbalance of Zn^(2+)homeostasis is closely related to the occurrence and metastasis of pancreatic cancer.Zn^(2+)homeostasis is regulated by two zinc transporter families,ZIP and ZnT,which mediate the processes of cell proliferation,differentiation and death.The ZIP protein family is mainly involved in DNA damage repair,cellular immunity,exosome secretion,and epithelial-mesenchymal transition(EMT)processes through RAS/RREB1 and cAMP/JAK/STAT signaling pathways,thereby affecting pancreatic cancer.The ZnT protein family mainly promotes the occurrence and development of pancreatic cancer through ERK,p38MAPK,NF-κB,and mTOR pathways.This review aims to provide some theoretical basis for the prevention,diagnosis,treatment and prognosis of pancreatic cancer.

关 键 词：锌 锌转运蛋白 胰腺癌 

分 类 号：R73[医药卫生—肿瘤]