连接蛋白30在运动型星形胶质细胞中局部调控肌动蛋白细胞骨架和机械重构  

Connexin 30 locally controls actin cytoskeleton and mechanical remodeling in motile astrocytes

作　　者：唐颖馨(编译) 

机构地区：[1]不详

出　　处：《神经损伤与功能重建》2024年第10期F0003-F0003,共1页Neural Injury and Functional Reconstruction

摘　　要：在大脑成熟过程中,星形胶质细胞形成了复杂的形态结构,展现出强烈的结构可塑性。连接蛋白30(Cx30),是一种在出生后表达的缝隙连接通道形成蛋白,在发育过程中通过控制细枝状突起的分支和延伸来动态调节星形胶质细胞的形态特性。然而,其背后的机制尚未被探索。我们在体外发现Cx30在星形胶质细胞中与肌动蛋白细胞骨架相互作用,并在细胞迁移期间抑制其结构重组和动态变化。During brain maturation,astrocytes establish complex morphologies unveiling intense structural plas-ticity.Connexin 30(Cx30),a gap-junction channel-forming protein expressed postnatally,dynamically regulates during development astrocyte morphological properties by controlling ramification and extension of fine process-es.However,the underlying mechanisms remain unexplored.Here,we found in vitro that Cx30 interacts with the actin cytoskeleton in astrocytes and inhibits its structural reorganization and dynamics during cell migration.

关 键 词：星形胶质细胞 连接蛋白 细胞迁移 肌动蛋白细胞骨架 结构可塑性 缝隙连接通道 形态特性 动态调节 

分 类 号：R741[医药卫生—神经病学与精神病学]