铁死亡相关基因MTDH调控乳腺癌的研究进展  

Research Progress on Ferroptosis-Related Gene MTDH in Regulation of Breast Cancer

作　　者：郭梦杰 南璐 刘广进 李元栋 GUO Mengjie;NAN Lu;LIU Guangjin;LI Yuandong(The First Clinical School of Shanxi Medical University,Taiyuan 030001,China;First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一临床医学院,山西太原030001 [2]山西医科大学第一医院,山西太原030001

出　　处：《肿瘤学杂志》2024年第7期545-550,共6页Journal of Chinese Oncology

基　　金：山西省科技厅科技成果转化引导专项(202204021301066)。

摘　　要：乳腺癌作为威胁女性健康的第一大癌,其治疗策略需要不断更新和完善。基因MTDH作为一个铁死亡过程的驱动基因,在乳腺癌中具有潜在的治疗价值。全文概述了MTDH在乳腺癌转移、耐药、免疫微环境、癌细胞干性中的作用以及其与铁死亡的相关性,显示其作为乳腺癌治疗的特异性靶标具有巨大潜力,但缺乏足够的临床研究数据支持。深入探索MTDH与乳腺癌及免疫的关系,有望找到新型治疗方法,克服目前乳腺癌治疗面临的转移及耐药难题,改善乳腺癌患者的治疗效果和预后。Breast cancer,as the leading cancer threatening women’s health,requires constant updates and improvements in treatment strategies.MTDH,as a driver gene in ferroptosis,has potential therapeutic value in breast cancer.This paper reviews the role of MTDH in the metastasis and drug resistance of breast cancer,immune microenvironment,cancer stemness,and its correlation with ferroptosis.It demonstrates that MTDH,as a specific target for breast cancer treatment,has tremendous potential,but lacks sufficient clinical research data.Therefore,a thorough exploration of the relationship of MTDH with breast cancer and its immunity is expected to identify novel treatment methods to overcome the drug resistance and improve the prognosis of breast cancer patients.

关 键 词：MTDH 乳腺癌 铁死亡 耐药性 免疫治疗 

分 类 号：R737.9[医药卫生—肿瘤]