外周血白细胞介素-6水平联合CD4^(+)/CD8^(+)比值评估胃癌严重程度和预测复发的临床价值分析  

Serum IL-6 Level Combined with CD4^(+)/CD8^(+) Ratio in Evaluate Severity and Predicting Recurrence of Gastric Cancer

作　　者：史敏敏 雷俊梅 崔萌萌 原培英 SHI Mingming;LEI Junmei;CUI Mengmeng;YUAN Peiying(Jincheng Second People's Hospital,Jingcheng 048000,China)

机构地区：[1]晋城市第二人民医院,山西晋城048000

出　　处：《肿瘤学杂志》2024年第7期599-603,共5页Journal of Chinese Oncology

摘　　要：[目的]分析外周血白细胞介素-6(interleukin-6,IL-6)水平联合CD4^(+)/CD8^(+)比值评估胃癌严重程度和预测复发的临床价值。[方法]选择2015年3月至2018年4月收治的120例胃癌患者为研究组,同期选择60名门诊健康体检者为对照组,对比两组的外周血IL-6水平、CD4^(+)/CD8^(+)比值,并对不同临床特征胃癌患者的外周血IL-6水平、CD4^(+)/CD8^(+)比值进行比较分析。随访5年,根据胃癌患者的复发情况进行分组,分析两组的外周血IL-6水平、CD4^(+)/CD8^(+)比值。采用受试者工作特征(receiver operating characteristic,ROC)曲线分析外周血IL-6水平联合CD4^(+)/CD8^(+)比值评估胃癌复发情况的临床价值。[结果]研究组的外周血IL-6水平明显高于对照组,CD4^(+)/CD8^(+)比值明显低于对照组(P均<0.001)。不同TNM分期、分化程度、淋巴结转移胃癌患者的外周血IL-6水平、CD4^(+)/CD8^(+)比值比较差异均有统计学意义(P均<0.001)。复发组(13例)的外周血IL-6水平明显高于未复发组(107例),CD4^(+)/CD8^(+)比值明显低于未复发组(P均<0.001)。ROC曲线结果显示,IL-6的曲线下面积为0.771,CD4^(+)/CD8^(+)的曲线下面积为0.720,两者联合的曲线下面积为0.835(P<0.001)。[结论]外周血IL-6水平高、低CD4^(+)/CD8^(+)比值与胃癌患者的病情严重程度相关。两者联合检测可作为预测胃癌复发的有效监测指标。[Objective]To analyze the clinical value of serum IL-6 level and CD4^(+)/CD8^(+) ratio in evaluate severity and predicting recurrence of gastric cancer.[Methods]A total of 120 patients with gastric cancer admitted from March 2015 to April 2018 were enrolled,and 60 healthy subjects were selected as controls.The serum IL-6 and CD4^(+)/CD8^(+) ratio of the two groups were compared;and their correlation with clinicopathological features of gastric cancer patients were analyzed.Patients were followed up for 5 years,the IL-6 level and CD4^(+)/CD8^(+) ratio were compared between patients with or without recurrence.The receiver operating characteristic(ROC)curve was used to analyze the value of IL-6 level combined with the ratio of CD4^(+)/CD8^(+) in predicting recurrence of gastric cancer.[Results]Compared with healthy controls,the IL-6 level was significantly higher and the CD4^(+)/CD8^(+) ratio was lower in the gastric cancer patients(all P<0.001).There were significant differences in IL-6 levels and CD4^(+)/CD8^(+) ratio among gastric cancer patients with different TNM stages,differentiation levels,and status of lymph node metastasis(all P<0.001).The IL-6 levels in the recurrent group(n=13)were significantly higher,and the CD4^(+)/CD8^(+) ratio was significantly lower than those in the non-recurrent group(n=107)(all P<0.001).ROC curve showed that the areas under the curve(AUC)of IL-6,CD4^(+)/CD8^(+) and combination of two indicators were 0.771,0.720 and 0.835,respectively(P<0.001).[Conclusion]The high serum IL-6 level and the low CD4^(+)/CD8^(+) ratio are associated with the severity of gastric cancer patients;combined detection of both may serve as a monitoring indicator for predicting gastric cancer recurrence.

关 键 词：白细胞介素-6 CD4^(+)/CD8^(+)比值 胃肿瘤 复发 

分 类 号：R735.2[医药卫生—肿瘤]