胰腺癌术后肝转移的诊疗进展  

Progress in diagnosis and treatment of liver metastasis after operation of pancreatic cancer

作　　者：童敬澍 毛书奇 吴胜东[2] 郑四鸣 陆才德[2] Tong Jingshu;Mao Shuqi;Wu Shengdong;Zheng Siming Lu Caide(Department of Hepatopancreatobiliary Surgery,the First Afiliated Hospital of Ningbo University,Ningbo 315010,China;Department of Hepatopancreatobiliary Surgery,Ningbo Medical Centre Lihuili Hospital,Ningbo 315040,China)

机构地区：[1]宁波大学附属第一医院肝胆胰外科,宁波315010 [2]宁波市医疗中心李惠利医院肝胆胰外科,宁波315040

出　　处：《中华转移性肿瘤杂志》2024年第4期394-398,共5页Chinese Journal of Metastatic Cancer

基　　金：宁波市医疗卫生品牌学科建设项目(PPXK2018-03);宁波市重点研发计划项目(2023Z210、2024Z179);李惠利科研培育项目(2022KYPYXM-L2)。

摘　　要：胰腺癌作为恶性程度较高的肿瘤,其发病率和死亡率逐年上升。尽管根治性手术切除是当前治疗的主要手段,但因其术后较高的复发率而限制了手术疗效的提高,特别是术后肝转移比重最大、预后最差更严重影响了患者生存时间。文章详细探讨了胰腺癌术后肝转移的机制理论、术后肝转移的分期、危险因素和预后,以及对术后肝转移的监测和早期诊断方法。此外,对外科手术、辅助化疗和免疫靶向等治疗方法的研究进展进行了梳理。Pancreatic cancer,known for its high malignancy,exhibits increasing incidence and mortality rates over the years.Despite radical surgical resection being the primary treatment,its high postoperative recurrence rates significantly impede improvements in surgical efficacy.Notably,liver metastasis after surgery,with the poorest prognosis,poses a substantial impact on patient survival.The review extensively discussed the theoretical mechanisms,staging,risk factors,and prognosis of postoperative liver metastasis of pancreatic cancer.Additionally,it also discussed the methods for monitoring and early diagnosis of postoperative liver metastasis,along with reviewing advancements in treatments such as surgical procedures,adjuvant chemotherapy,and immunotherapy.

关 键 词：胰腺癌 根治性手术 肝转移 复发 

分 类 号：R735.9[医药卫生—肿瘤]