响应面法优化密蒙花黄色素的快速提取工艺  

Optimization of Rapid Extraction of Yellow Pigment from Buddlejae Flos by Response Surface Methodology

作　　者：刘红 田洪根 LIU Hong;TIAN Hong-gen(Binzhou Inspection and Testing Center,Binzhou 256600,China;Binzhou Key Laboratory of Chemical Drug Development and Quality Control,Binzhou 256600,China)

机构地区：[1]滨州市检验检测中心,山东滨州256600 [2]滨州市化学药物研发与质量控制重点实验室(筹),山东滨州256600

出　　处：《食品与药品》2024年第5期426-430,共5页Food and Drug

基　　金：滨州市社会科学相关研究专项课题(编号:2024-dybz-62)。

摘　　要：目的优化密蒙花黄色素的闪式提取工艺。方法以黄色素提取得率为指标,采用响应面设计法对闪式提取过程中的乙醇浓度、提取转速及时间等因素进行优化。结果闪式提取密蒙花黄色素的最佳工艺条件为:固定料液比30 ml/g,调整乙醇浓度46%,提取转速8650 r/min、提取时间104 s。在此条件下,黄色素得率可达69.22±1.4mg/g。结论该方法高效、稳定、可靠,为密蒙花黄色素的深入开发提供了一定依据。Objective To optimize the flash extraction conditions of yellow pigment from Buddlejae Flos.Methods With the yield of yellow pigment as the indicator,the ethanol concentration,extraction rotation speed and extraction time were optimized by response surface methodology(RSM).Results The optimal extraction conditions included liquid to solid ratio of 30 ml/g,ethanol concentration of 46%,extraction rotation speed of 8650 r/min and extraction time of 104 s.The yield of yellow pigment reached 69.22±1.4 mg/g.Conclusion The method is efficient,stable and reliable,which can provide a strong support for the further development of yellow pigment from Buddlejae Flos.

关 键 词：密蒙花 黄色素 闪式提取 响应面法 

分 类 号：R284.2[医药卫生—中药学]