Gold mineralized“hybrid nanozyme bomb”for NIR-Ⅱtriggered tumor effective permeation and cocktail therapy  

作　　者：Ji Liu Dongsheng He Tianjiao Hao Yumin Hu Yan Zhao Zhen Li Chang Liu Daquan Chen Qiyue Wang Xiaofei Xin Yan Shen 

机构地区：[1]Department of Pharmaceutics,State Key Laboratory of Nature Medicines,China Pharmaceutical University,Nanjing 210009,China [2]Wuxi Hequan Pharmaceutical Co.,Ltd.,Wuxi 214029,China [3]Beijing Xinghao Yingsheng Pharmaceutical Co.,Ltd.,Beijing 102609,China [4]School of Pharmacy,Yantai University,Yantai 264005,China [5]School of Pharmaceutical Science,Nanjing Tech University,Nanjing 211816,China

出　　处：《Chinese Chemical Letters》2024年第9期243-249,共7页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81972892)。

摘　　要：Lung cancer is one of the most common malignant tumors with the fastest increase in the incidence rate and mortality.Even after maximum tumor resection assistance with a radiotherapy and chemotherapy combination,the recurrence of non-small cell lung cancer is still inevitable.In addition,low targeting efficiency and poor permeability of drug delivery systems strongly affect the therapeutic efficiency of anti-cancer drugs on non-small cell lung cancer.Here we designed a gemcitabine(GEM)loaded arginineglycine-aspartic acid-cysteine(RGDc)-modified gold mineralization“hybrid nanozyme bomb”(RGTG)to overcome those obstacles.RGDc modification improved the active targeting of liposomes to the tumor tissues with the second near-infrared(NIR-Ⅱ)-triggered gold-shell disruption and GEM release.The collapsed gold-shell particles with a smaller size could penetrate the tumor solid barrier and act as photothermal therapy(PTT)agents to improve PTT therapy and starvation therapy via generating gluconic acid and reactive oxygen species(ROS).Moreover,the resting reversal effect of gold particles on tumor fibroblasts can achieve accelerating tumor penetration of gold particles and GEM.Compared to monotherapy,RGTG showed significant improvement in tumor inhibition,with a tumor volume reduction of 83%compared to the control group,which provides a promising tumor treatment platform for non-small cell lung cancer(NSCLC).

关 键 词：Gold mineralized Hybrid nanozyme bomb Starvation therapy Cocktail therapy NSCLC 

分 类 号：R73-36[医药卫生—肿瘤]