Inhaled multilevel size-tunable,charge-reversible and mucus-traversing composite microspheres as trojan horse:Enhancing lung deposition and tumor penetration  

作　　者：Lishan Xiong Xinyuan Li Xiaojie Lu Zhendong Zhang Yan Zhang Wen Wu Chenhui Wang 

机构地区：[1]Chongqing Key Laboratory of Natural Product Synthesis and Drug Research,School of Pharmaceutical Sciences,Chongqing University,Chongqing 401331,China [2]Chongqing Key Laboratory of High Active Traditional Chinese Drug Delivery System,Chongqing Engineering Research Center of Pharmaceutical Sciences,Chongqing Medical and Pharmaceutical College,Chongqing 404120,China

出　　处：《Chinese Chemical Letters》2024年第9期273-278,共6页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.52273123);the Natural Science Foundation of Chongqing,China(No.CSTB2022NSCQ-MSX0474);the Talent-introduction Program of Chongqing Medical and Pharmaceutical College(No.YGZRC2023103).

摘　　要：Dry powder inhalation represents a promising approach for the treatment of lung cancer,offering several advantages such as enhanced targeting,improved bioavailability,and reduced toxicity.However,traditional dry powder formulations suffer from limitations,notably low pulmonary delivery efficiency and inadequate penetration into tumor tissues,thereby limiting their therapeutic efficacy.In response to these challenges,we have developed an innovative trojan horse strategy,harnessing an inhalable nanoparticlein-microsphere system characterized by tunable size,reversible charge,and mucus-penetrating capabilities.The inhalable nanoparticle-in-microsphere system exhibit stable structural properties,excellent environmental responsiveness and high biocompatibility.More importantly,the therapeutic effect of MTX@PAMAM@HA@Gel(MPHG)was demonstrated in vitro and in vivo.This system offers improved pulmonary delivery efficiency,enhanced drug retention within tumor tissues,and effective penetration,thus representing a promising strategy in lung cancer treatment.

关 键 词：Pulmonary delivery Size-tunable nanoparticles Charge-reversible nanoparticles Mucus penetration Lung cancer 

分 类 号：R734.2[医药卫生—肿瘤]