代谢相关脂肪性肝病的发病机制与中医病机  

Research advances in the pathogenesis of metabolic associated fatty liver disease

作　　者：姚树坤[1] 刘婧 周天惠 YAO Shukun;LIU Jing;ZHOU Tianhui(Department of Gastroenterology,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]中日友好医院消化科,北京100029

出　　处：《临床肝胆病杂志》2024年第10期1954-1958,共5页Journal of Clinical Hepatology

基　　金：北京化工大学-中日友好医院生物医学转化工程研究中心联合基金项目(XK2022-07)。

摘　　要：代谢相关脂肪性肝病(MAFLD)是目前全球最常见的肝脏疾病。MAFLD不仅本身易进展为肝炎、肝纤维化和肝硬化等不良结局,还常常伴发共患病,如糖尿病、高血压、高血脂、高尿酸血症及心脑血管疾病。病因治疗是疾病治疗的基石,由于MAFLD具有复杂性和不良转归,因此,探索MAFLD的发病机制,并据此开发有效的防治方案和新药等具有重大意义。本文将从遗传因素,饮食不节和氧化应激,脾胃湿热和胰岛素抵抗,湿热邪气和有机酸代谢,肠道微生态几个方面对MAFLD的发病机制进行综述。Metabolic associated fatty liver disease(MAFLD)is currently the most common liver disease around the world.MAFLD may easily progress to the adverse outcomes such as hepatitis,liver fibrosis,and liver cirrhosis,and it is often accompanied by comorbidities such as diabetes,hypertension,hyperlipidemia,hyperuricemia,and cardiovascular and cerebrovascular diseases.Etiological treatment is the cornerstone of MAFLD treatment,and due to the complexity and adverse outcome of MAFLD,it is of great significance to explore the pathogenesis of MAFLD and develop effective prevention and treatment regimens and drugs.This article reviews the pathogenesis of MAFLD from the aspects of genetic factors,improper diet and oxidative stress,spleen-stomach damp-heat and insulin resistance,damp-heat and pathogenic Qi,organic acid metabolism,and intestinal microecology.

关 键 词：非酒精性脂肪性肝病 脂类代谢 中医病因和病机 

分 类 号：R575.5[医药卫生—消化系统]