CD8+T淋巴细胞在非酒精性脂肪性肝炎中的作用  

The role of CD8+T cells in nonalcoholic steatohepatitis

作　　者：赵一鸣 李开楊 杨梅 赵琦 ZHAO Yiming;LI Kaiyang;YANG Mei;ZHAO Qi(The Second Clinical Medical School of Guizhou University of Traditional Chinese Medicine,Guiyang 550002,China;Department of Clinical Laboratory,The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550001,China;Department of Gastroenterology,The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550001,China)

机构地区：[1]贵州中医药大学第二临床医学院,贵阳550002 [2]贵州中医药大学第二附属医院检验科,贵阳550001 [3]贵州中医药大学第二附属医院消化内科,贵阳550001

出　　处：《临床肝胆病杂志》2024年第10期2087-2091,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金项目(82160866);贵州省科技计划项目(黔科合基础-ZK[2023]一般433);贵州省卫生健康委科学技术基金资助项目(gzwkj2023-208);贵州省高等学校重点实验室(黔教技[2023]017号)。

摘　　要：非酒精性脂肪性肝炎(NASH)是一种与代谢综合征密切相关的肝脏疾病,其发病机制包括胰岛素抵抗、脂质代谢紊乱、炎症反应等方面。本文简述了CD8+T淋巴细胞通过Fas-Fas配体(FasL)信号通路、释放穿孔素和颗粒酶以及分泌肿瘤坏死因子(TNF)α等细胞因子三种途径发挥细胞毒性作用特异性杀伤病毒及肿瘤靶细胞参与免疫调节;同时总结了CD8+T淋巴细胞促进巨噬细胞招募且与自然杀伤T淋巴细胞协同参与脂肪组织炎症发展,并通过自身攻击及表观遗传学机制导致肝损伤,促进NASH发病。由此得知CD8+T淋巴细胞可能成为NASH新的治疗靶点,未来继续深入研究CD8+T淋巴细胞在NASH中影响发病进程的具体机制有利于进一步指导临床治疗。Nonalcoholic steatohepatitis(NASH)is a liver disease closely associated with metabolic syndrome,and its pathogenesis includes insulin resistance,lipid metabolism disorders,and inflammatory response.This article briefly describes how CD8+T cells exert a cytotoxic effect through the three pathways of the Fas-Fas ligand signaling pathway,the release of perforin and granzymes,and the secretion of tumor necrosis factor-αand other cytokines,and these mechanisms allow CD8+T cells to specifically kill virus-infected cells and tumor target cells,thereby participating in immune regulation.At the same time,this article summarizes that CD8+T cells promote the recruitment of macrophages cooperate with natural killer T cells to participate in the development of adipose tissue inflammation,and lead to liver injury through automatic attack and epigenetic mechanisms,finally promoting the pathogenesis of NASH.It is concluded that CD8+T cells may become a new therapeutic target for NASH,and in-depth research on the specific mechanism of CD8+T cells affecting the pathogenesis in NASH in the future may help to further guide clinical treatment.

关 键 词：非酒精性脂肪性肝病 CD8阳性T淋巴细胞 脂肪组织 炎症 表观基因组学 

分 类 号：R575.5[医药卫生—消化系统]