Apolipoprotein E elicits targetdirected miRNA degradation to maintain neuronal integrity  

作　　者：Jiazi Tan Chin-Tong Ong 

机构地区：[1]Temasek Life Sciences Laboratory,National University of Singapore,Singapore [2]Department of Biological Sciences,National University of Singapore,Singapore

出　　处：《Neural Regeneration Research》2025年第9期2577-2578,共2页中国神经再生研究（英文版）

基　　金：supported by core funding provided by Temasek Life Sciences Laboratory(to CTO)。

摘　　要：Apolipoprotein E has diverse functions in neurons:Apolipoprotein E(ApoE)is a glycoprotein that primarily regulates lipid metabolism and transport in the central nervous system.There are three predominant human ApoE protein isoforms with cysteine and arginine substitutions at amino acid positions 112 and 158 that impact their lipidation and related functions(Flowers and Rebeck,2020).ApoE2 is characterized by Cys112 and Cys158,ApoE3 by Cys112 and Arg158,whereas ApoE4 contains Arg112 and Arg158.

关 键 词：METABOLISM GLYCOPROTEIN MAINTAIN 

分 类 号：Q421[生物学—神经生物学]