Aggresome-aggrephagy transition process:geting closer to the functional roles of HDAC6 and BAG3  

作　　者：Hagen Körschgen Christian Behl 

机构地区：[1]The Autophagy Lab,Institute of Pathobiochemistry,University Medical Center of the Johannes Gutenberg University Mainz,Mainz,Germany

出　　处：《Neural Regeneration Research》2024年第6期1181-1182,共2页中国神经再生研究（英文版）

基　　金：supported by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)Project-ID 259130777-SFB 1177(to CB)。

摘　　要：Misfolding of proteins as well as their aggregation is a major driver of age-related neurodegenerative diseases.Hence,cells have evolved sophisticated protein quality control mechanisms.Mainly the ubiquitin-proteasome-system(UPS)and the autophagosome-lysosome-system,specifically a macroautophagy pathway called“aggrephagy”,govern the disposal of aggregates.However.

关 键 词：CLOSER SYSTEM TRANSITION 

分 类 号：R741[医药卫生—神经病学与精神病学]