Future directions:combination of acupuncture with mesenchymal stem cells for Parkinson’s disease  

作　　者：Shan Zhong Song-Zhe He Xi-Lin Wang 

机构地区：[1]Department of Acupuncture and Moxibustion,Guilin Municipal Hospital of Traditional Chinese Medicine,Guangxi University of Chinese Medicine,Guilin 541002,China [2]Department of Clinic Laboratory,Affiliated Hospital of Guilin Medical University,Guilin 541001,China.

出　　处：《Integrative Medicine Discovery》2024年第23期1-6,共6页

基　　金：supported by grants from the Natural Science Foundation of Guangxi Zhuang Autonomous Region(2023GXNSFBA026154 to Shan Zhong,2024GXNSFAA010410 to Xilin Wang);self-financing project of Traditional Chinese Medicine Administration of Guangxi Zhuang Autonomous Region(GXZYC20230355 to Songzhe He);Scientific Research Foundation of Guangxi Traditional Chinese Medical University(2022MS064 to Xilin Wang).

摘　　要：Parkinson’s disease(PD)is a progressive chronic disease currently with no radical cure drugs and means due to the complex pathological mechanisms and limited regenerative capacity of neurons.Acupuncture aids in neuronal regeneration via various signaling routes like ROCK,Wnt,and Notch,safeguarding dopaminergic neurons against inflammation,oxidative stress,and cell death,which in turn enhances the progression of PD progression.Numerous research findings indicate that integrating acupuncture with mesenchymal stem cells(MSCs)transplantation is more effective than using either acupuncture or MSCs infusion alone.The combined treatment improves the survival rate of MSCs,promotes the generation of functional neural networks by stimulating the secretion of neurotrophic factors,and ultimately improves the disease microenvironment.In this review,we state the neuroprotective effects of acupuncture or MSCs treament alone in PD,then summarize the application of acupuncture combined with MSCs therapy in other diseases.Consequently,we anticipate that integrating acupuncture with MSCs transplantation may emerge as a novel and efficient approach for managing PD.This possibility needs to be verified through further basic and clinical research.

关 键 词：Parkinson’s disease ACUPUNCTURE mesenchymal stem cells dopaminergic neuron THERAPY 

分 类 号：R742.5[医药卫生—神经病学与精神病学]