Wilson病患者冲动性对数字成瘾倾向的影响及相关因素  

The impact of impulsivity on digital addiction tendencies and related factors in Wilson disease patients

作　　者：柯洁茹 程亚杰 王共强 金平 马心锋 林康 童广安 叶群荣 韩咏竹 KE Jieru;CHENG Yajie;WANG Gongqiang;JIN Ping;MA Xinfeng;LIN Kang;TONG Guangan;YE Qunrong;HAN Yongzhu(The Affiliated Hospital of Institute of Neurology,Anhui University of Tradition Chinese Medicine,Hefei 230061,China)

机构地区：[1]安徽中医药大学神经病学研究所,合肥230038 [2]安徽中医药大学研究生院,合肥230038 [3]安徽中医药大学神经病学研究所附属医院,合肥230038

出　　处：《中国神经精神疾病杂志》2024年第7期423-429,共7页Chinese Journal of Nervous and Mental Diseases

基　　金：安徽省高校自然科学研究基金重点项目(编号:No.2023AH050793)。

摘　　要：目的探讨Wilson病(Wilson disease,WD)患者冲动性对数字成瘾倾向的影响及其相关因素。方法纳入66例WD患者为研究对象,根据临床表现分为脑型组42例、肝型组24例。采用网络成瘾量表(internet addiction test,IAT)评估患者网络成瘾倾向,总分>50分界定为具有网络成瘾倾向;使用Barratt冲动量表中文版(the Chinese version of the Barratt impulsiveness scale,11version,BIS-11-C)评估患者冲动性;手机依赖量表(mobile phone addiction index,MPAI)评估对手机使用的依赖程度;通过颅脑MRI检查患者病变脑区的部位和累计频次。结果66例WD患者中有数字成瘾倾向者45例(68.2%),其中脑型组中35例(53.0%)、肝型组中10例(15.2%),两组成瘾倾向者比例差异有统计学意义(P=0.001)。脑型组患者在BIS-11-C、MPAI量表多项因子分上高于肝型组(P<0.05)。所有患者MPAI量表中失控性因子分与BIS-11-C量表中的注意力冲动性因子分(r=0.499,P=0.001)、运动冲动性因子分(r=0.553,P=0.001)、无计划冲动性因子分(r=0.535,P=0.001)、冲动控制总分(r=0.653,P=0.001)正相关。线性回归分析显示注意力冲动性因子分与额叶病变(B=-1.634,P=0.018)相关联,失控性因子分与额叶病变(B=-3.609,P=0.023)相关联,戒断性因子分与丘脑病变(B=-5.047,P=0.007)、额叶病变(B=-2.204,P=0.024)相关联,逃避性因子分与顶叶病变(B=-1.867,P=0.032)相关联,低效性因子分与壳核病变(B=-1.789,P=0.016)、额叶病变(B=-1.592,P=0.044)相关联。结论脑型WD患者较肝型有更高的数字成瘾倾向,数字成瘾倾向与冲动性相关。WD患者的数字成瘾倾向可能与壳核、丘脑、额叶等多个脑区病变引起的冲动控制障碍有关。Objective To explore the influence of impulsivity on digital addiction tendencies in patients with Wilson disease(WD)and its related factors.Methods A total of 66 patients with WD were included in the study which were divided into neurological WD group(42 cases)and hepatic WD group(24 cases)according to clinical manifestations.Sixty-six WD patients were included as the study subjects,including 24 cases of hepatic WD and 42 cases of neurological WD.The Chinese version of the Barratt impulsiveness scale(BIS-11-C)was used to assess patients’impulsiveness.Mobile phone addiction index(MPAI)evaluates the degree of dependence on mobile phone use.Cranial MRI was used to examine the location and cumulative frequency of the diseased brain region.Results Among the 66 WD patients,45 cases(68.2%)had the tendency of digital addiction,including 35 cases(53.0%)in the neurological WD group and 10 cases(15.2%)in the hepatic WD group.There was a statistically significant difference in the proportion of the two types of WD patients(P=0.001).The scores of BIS-11-C and MPAI scales in neurological WD group were higher than those in hepatic WD group(P<0.05).The out-of-control score in the MPAI scale is positively correlated with the attention impulsivity score(r=0.499,P=0.001),motor impulsivity score(r=0.553,P=0.001),unplanned impulsivity score(r=0.535,P=0.001),and impulse control score(r=0.653,P=0.001)in the BIS-11-C scale.Linear regression analysis showed a correlation between attention impulsivity score and frontal lobe lesions(B=-1.634,P=0.018).There was a correlation between loss of control score and frontal lobe lesions(B=-3.609,P=0.023).The withdrawal score was associated with the thalamus lesions(B=-5.047,P=0.007)and frontal lobe lesions(B=-2.204,P=0.024).Avoidance score was associated with parietal lobe lesions(B=-1.867,P=0.032).The low efficacy score was associated with the putamen lesions(B=-1.789,P=0.016)and frontal lobe lesions(B=-1.592,P=0.044).Conclusion Neurological WD patients have higher tendency of digital addiction

关 键 词：WILSON病 肝豆状核变性 冲动性 数字成瘾 网络成瘾 手机依赖 脑机制 

分 类 号：R742.4[医药卫生—神经病学与精神病学]