幽门螺杆菌感染及根除影响肠道微生态紊乱相关机制的研究进展  

Research progress of Helicobacter pylori infection and eradication of related mecha-nisms affecting intestinal microecological

作　　者：高浏璐 何昱静 郑英 李斌 卢利霞 李初谊 张久聪 于晓辉 GAO Liulu;HE Yujing;ZHENG Ying;LI Bin;LU Lixia;LI Chuyi;ZHANG Jiucong;YU Xiaohui(The 940th Clinical Medical College,Northwest Minzu University,Lanzhou 730030;Department of Gastroenterology,the 940th Hospital of Joint Service Logistics Support Force of PLA;Laboratory of Basic Medicine,the 940th Hospital of Joint Logistic Support Force,Gansu Laboratory of Stem Cell and Gene Medicine,China)

机构地区：[1]西北民族大学九四〇临床医学院,甘肃兰州730030 [2]中国人民解放军联勤保障部队第九四〇医院消化内科 [3]中国人民解放军联勤保障部队第九四〇医院基础医学实验室,甘肃省干细胞与基因药物实验室

出　　处：《胃肠病学和肝病学杂志》2024年第10期1372-1376,共5页Chinese Journal of Gastroenterology and Hepatology

基　　金：甘肃省科技计划项目(21JR7RA017);中央高校基本科研业务费专项资金资助(31920230045);甘肃省自然科学基金(21JR7RA002);甘肃省青年科技基金(23JRRA1675)。

摘　　要：幽门螺杆菌(Helicobacter pylori,H.pylori)是引起急慢性胃肠病及胃肠外疾病常见的致病菌,根除H.pylori对治疗起到关键作用,H.pylori的全球感染率一直居高不下,且近年来由于H.pylori耐药等机制导致H.pylori根除效果欠佳,H.pylori感染及其根除过程还会影响肠道微生态的改变,其发生机制异常复杂,是目前医学领域研究的热点。本文对H.pylori感染和根除导致肠道微生态紊乱相关机制的最新文献进行归纳、总结,以期为临床抗H.pylori治疗过程中如何减少肠道菌群改变和失衡,进而提高H.pylori根除疗效,减少根除治疗引起的不良反应提供一定的理论依据。Helicobacter pylori(H.pylori)is a common pathogenic bacterium that causes acute and chronic gastrointestinal diseases and parenteral diseases.Eradication of H.pylori plays a key role in the treatment.The global infection rate of H.pylori is always high,and in recent years,the eradication effect of H.pylori is poor due to H.pylori drug resistance and other mechanisms.H.pylori infection and its eradication process can also affect the changes of intestinal microecology,and its mechanism is extremely complex,which is a hot topic in the medical field.This paper summarized the latest literature on the mechanism of intestinal microecological disturbance caused by H.pylori infection and eradication,in order to provide certain theoretical basis for how to reduce the change and imbalance of intestinal flora during clinical anti-H.pylori treatment,so as to improve the curative effect of H.pylori eradication and reduce the adverse reactions caused by eradication treatment.

关 键 词：幽门螺杆菌 肠道微生态 根除疗法 

分 类 号：R57[医药卫生—消化系统]