改善间充质干细胞移植治疗肝硬化疗效方法的研究进展  

Research progress of methods to improve the efficacy of mesenchymal stem cells transplantation in the treatment of liver cirrhosis

作　　者：熊芷玉 江应安[1] XIONG Zhiyu;JIANG Ying′an(Department of Infections Disease,Renmin Hospital of Wuhan University,Wuhan 430000,China)

机构地区：[1]武汉大学人民医院感染科,湖北武汉430000

出　　处：《胃肠病学和肝病学杂志》2024年第10期1401-1404,共4页Chinese Journal of Gastroenterology and Hepatology

基　　金：武汉大学抗衰老研究中心教育发展基金会(2002330)。

摘　　要：间充质干细胞(mesenchymal stem cells,MSCs)作为一种新兴的治疗手段,在肝硬化治疗中展现出巨大潜力。为进一步提高MSC疗法在肝硬化治疗中的效果,本文综述了近年来的相关研究进展。通过检索PubMed和CNKI中国期刊全文数据库中的“肝硬化、肝纤维化、间充质干细胞、归巢、外泌体”等关键词,筛选了2010年至2024年间发表的文献,共纳入36篇与MSCs治疗肝硬化相关的研究进行分析总结。研究表明,优化MSCs的培养条件有助于有效维持细胞活力,并促进其大规模增殖和分化。此外,提高MSCs的归巢效率可以增加其在肝脏中的定植,从而增强肝硬化的治疗效果。通过调控或诱导MSCs相关的外泌体产生,并提高MSCs分泌组中细胞因子的活性,有望更有效地改善肝硬化的病理进程。这些策略为MSCs在肝硬化治疗中的应用提供了新的研究方向和思路。Mesenchymal stem cells(MSCs)have emerged as a promising therapeutic strategy for the treatment of liver cirrhosis.To further enhance the therapeutic efficacy of MSC-based interventions in liver cirrhosis,this review summarized recent advancements in the field.A comprehensive literature search was conducted in the PubMed and CNKI databases using keywords such as liver cirrhosis,liver fibrosis,mesenchymal stem cells,homing and exosomes identifying 36 relevant studies published between 2010 and 2024 for analysis.Findings indicate that optimizing MSC culture conditions is crucial for maintaining cell viability and promoting extensive proliferation and differentiation.Moreover,enhancing MSC homing efficiency can increase hepatic engraftment,thereby improving therapeutic outcomes in liver cirrhosis.Modulating or inducing the production of MSC-derived exosomes,as well as enhancing the bioactivity of cytokines within the MSC secrete,holds potential for effectively mitigating the pathological progression of liver cirrhosis.These strategies offer novel insights and avenues for advancing the application of MSCs in the treatment of liver cirrhosis.

关 键 词：肝硬化 间充质干细胞 疗效 归巢 外泌体 

分 类 号：R575[医药卫生—消化系统]